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61 Article(s) on File
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The X-linked mental retardation protein OPHN1 interacts with Homer1b/c to control spine endocytic zone positioning and expression of synaptic potentiation
Nakano-Kobayashi A,
Tai Y,
Kasri NN,
Van Aelst L

Journal of Neuroscience
  34 (26): 8665-8671; Jun 25 2014   NLM
[Abstract]
[DOI] [Full Text]

Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation
Murray DW,
Didier S,
Chan A,
Paulino V,
Van Aelst L,
Ruggieri R,
Tran NL,
Byrne AT,
Symons M

British Journal of Cancer
  110 (5): 1307-5; Mar 4 2014   Nlm
[Abstract]
[DOI] [Full Text]

WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation
Anne SL,
Govek EE,
Ayrault O,
Kim JH,
Zhu X,
Murphy DA,
Van Aelst L,
Roussel MF,
Hatten ME

PLoS ONE
  8 (11): Nov 26 2013  
[Abstract]
[DOI] [Full Text]

Introduction to the ECR special issue on the roles of small GTPases
Boettner B,
Van Aelst L

Experimental Cell Research
  319 (15): 2309; Sep 10 2013   NLM
[DOI] [Full Text]

DOK2 inhibits EGFR-mutated lung adenocarcinoma
Berger AH,
Chen M,
Morotti A,
Janas JA,
Niki M,
Bronson RT,
Taylor BS,
Ladanyi M,
Van Aelst L,
Politi K,
Varmus HE,
Pandolfi PP

PLoS One
  8 (11): e79526; 2013   Nlm
[Abstract]
[DOI] [Full Text]

DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis
Yang YT,
Wang CL,
Van Aelst L

Nat Neurosci
  15 (9): 1201-10; Aug 12 2012   NLM
[Abstract]
[DOI] [Full Text]

Functional analysis of the protein phosphatase activity of PTEN
Zhang XC,
Piccini A,
Myers MP,
Van Aelst L,
Tonks NK

Biochem J
  444 (3): 457-64; Jun 15 2012   NLM
[Abstract]
[DOI] [Full Text]

Signaling and gradients: whats going down?
Hill CS,
Van Aelst L

Current Opinion in Cell Biology
  24 (2): 155-157; Apr 2012  
[Abstract]
[DOI] [Full Text]

Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins
Kang H,
Davis-Dusenbery BN,
Nguyen PH,
Lal A,
Lieberman J,
Van Aelst L,
Lagna G,
Hata A

Journal of Biological Chemistry
  287 (6): 3976-3986; Feb 3 2012  
[Abstract]
[DOI] [Full Text]

Rapid Synthesis of the X-Linked Mental Retardation Protein OPHN1 Mediates mGluR-Dependent LTD through Interaction with the Endocytic Machinery
Nadif Kasri N,
Nakano-Kobayashi A,
Van Aelst L

Neuron
  72 (2): 300-315; Oct 20 2011   PMC3206629
[Abstract]
[DOI] [Full Text]

The role of Rho GTPase proteins in CNS neuronal migration
Govek EE,
Hatten ME,
Van Aelst L

Developmental Neurobiology
  71 (6): 528-553; Jun 2011  
[Abstract]
[DOI]

Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformation
Janas JA,
Van Aelst L

Mol Cell Biol
  31 (13): 2552-2565; May 2 2011   Array
[Abstract]
[DOI]

Regulation of the Postsynaptic Cytoskeleton: Roles in Development, Plasticity, and Disorders
Svitkina T,
Lin WH,
Webb DJ,
Yasuda R,
Wayman GA,
Van Aelst L,
Soderling SH

J Neurosci
  30 (45): 14937-14942; Nov 10 2010   PMCID: PMC3074493
[Abstract]
[DOI] [Full Text] [PDF]

Signaling mechanisms
Van Aelst L,
Caroni P

Curr Opin Neurobiol
  20 (0): 1-3; Aug 21 2010  
[Abstract]
[DOI] [Full Text] [PDF]

Control of cell adhesion dynamics by Rap1 signaling
Boettner B,
Van Aelst L

Curr Opin Cell Biol
  21 (5): 684-693 ; Oct 2009   PMC2841981
[Abstract]
[DOI] [Full Text] [PDF]

The Rho-Linked Mental Retardation Protein OPHN1 Controls Synaptic Vesicle Endocytosis via Endophilin A1
Nakano-Kobayashi A,
Nadif Kasri N,
Newey SE,
Van Aelst L

Curr Biol
  19 (13): 1133-1139 ; Jul 14 2009   PMCID: PMC2711225
[Abstract]
[DOI] [Full Text] [PDF]

The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors
Nadif Kasri N,
Nakano-Kobayashi A,
Malinow R,
Li B,
Van Aelst L

Genes Dev
  23 (11): 1289-1302; Jun 2009   PMCID: PMC2701582
[Abstract]
[DOI] [Full Text] [PDF]

Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome
Hu HL,
Qin Y,
Bochorishvili G,
Zhu YH,
van Aelst L,
Zhu JJ

Journal of Neuroscience
  28 (31): 7847-7862; Jul 2008  
[Abstract]
[DOI] [Full Text] [PDF]

DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma
Xue W,
Krasnitz A,
Lucito R,
Sordella R,
Van Aelst L,
Cordon-Cardo C,
Singer S,
Kuehnel F,
Wigler MH,
Powers S,
Zender L,
Lowe SW

Genes Dev
  22 (11): 1439-44; Jun 1 2008   PMCID: PMC2418580
[Abstract]
[DOI] [Full Text] [PDF]

Characterization of Oligophrenin -1, a RhoGAP Lost in Patients Affected with Mental Retardation: Lentiviral Injection in Organotypic Brain Slice Cultures
Nadif Kasri N,
Govek EE,
Van Aelst L

Methods Enzymol
  439 (0): 255-266; Mar 26 2008  
[Abstract]
[DOI] [Full Text] [PDF]

Dialogue between RhoA/ROCK and Members of the Par Complex in Cell Polarity
Sordella R,
Van Aelst L

Dev Cell
  14 (2): 150-2; Feb 2008  
[Abstract]
[DOI] [Full Text] [PDF]

Rho-linked genes and neurological disorders
Nadif Kasri N,
Van Aelst L

Pflügers Archiv European Journal of Physiology
  455 (5): 787-797; Feb 2008  
[Abstract]
[DOI] [Full Text] [PDF]

The Rap GTPase Activator Drosophila PDZ-GEF Regulates Cell Shape in Epithelial Migration and Morphogenesis
Boettner B,
Van Aelst L

Mol Cell Biol
  27 (22): 7966-7980; Nov 2007   PMCID: PMC2169160
[Abstract]
[DOI] [Full Text] [PDF]

Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis
Zhao M,
Janas JA,
Niki M,
Pandolfi PP,
Van Aelst L

Mol Cell Biol
  26 (7): 2479-89; Apr 2006  
[Abstract]
[DOI] [Full Text] [PDF]

Lentiviral delivery of RNAi in hippocampal neurons
Janas JA,
Skowronski J,
Van Aelst L

Methods Enzymol
  406 (0): 593-605; 2006  
[Abstract]
[DOI] [Full Text] [PDF]

Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging
Yasuda R,
Harvey CD,
Zhong H,
Sobczyk A,
Van Aelst L,
Svoboda K

Nature Neuroscience
  9 (2): 283-291; 2006  
[Abstract]
[DOI] [Full Text] [PDF]

State-dependent Ras signaling and AMPA receptor trafficking
Qin Y,
Zhu YH,
Baumgart JP,
Stornetta RL,
Seidenman K,
Mack V,
van Aelst L,
Zhu JJ

Genes Development
  19 (17): 2000-2015; Sep 2005  
[Abstract]
[DOI] [Full Text] [PDF]

Erratum: Rap2-JNK removes synaptic AMPA receptors during depotentiation (vol 46, pg 905, 2005)
Zhu YH,
Pak D,
Qin Y,
McCormack SG,
Kim MJ,
Baumgart JP,
Velamoor V,
Auberson YP,
Osten P,
van Aelst L,
Sheng M,
Zhu JJ

Neuron
  47 (2): 321-321; Jul 2005  
[DOI]

Role of Dok-1 and Dok-2 in leukemia suppression
Niki M,
Di Cristofano A,
Zhao M,
Honda H,
Hirai H,
Van Aelst L,
Cordon-Cardo C,
Pandolfi PP

J Exp Med
  200 (12): 1689-95; Dec 20 2004   PMCID: PMC2211998
[Abstract]
[DOI] [Full Text] [PDF]

Assembly of turnip yellow mosaic virus replication complexes: Interaction between the proteinase and polymerase domains of the replication proteins
Jakubiec A,
Notaise J,
Tournier V,
Hericourt F,
Block MA,
Drugeon G,
van Aelst L,
Jupin I

Journal of Virology
  78 (15): 7945-7957; Aug 2004  
[Abstract]
[DOI] [Full Text] [PDF]

Rho GTPases and activity-dependent dendrite development
Van Aelst L,
Cline HT

Curr Opin Neurobiol
  14 (3): 297-304; Jun 2004  
[Abstract]
[DOI]

Knockdown of the X-linked mental retardation protein, oligophrenin-1, affects dendritic spine morphology
Govek EE,
Newey S,
Van Aelst L

Faseb Journal
  18 (8): C310-C310; May 2004  
[Full Text]

The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis
Govek EE,
Newey SE,
Akerman CJ,
Cross JR,
Van der Veken L,
Van Aelst L

Nat Neurosci
  7 (4): 364-72; Apr 2004  
[Abstract]
[DOI]

The AF-6 homolog Canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryo
Boettner B,
Harjes P,
Ishimaru S,
Heke M,
Fan HQ,
Qin Y,
Van Aelst L,
Gaul U

Genetics
  165 (1): 159-169; Sep 2003  
[Abstract]
[Full Text]

Ras and Rap control AMPA receptor trafficking during synaptic plasticity
Zhu JJ,
Qin Y,
Zhao MM,
Van Aelst L,
Malinow R

Cell
  110 (4): 443-455; Aug 2002  
[Abstract]
[DOI] [Full Text] [PDF]

The RASputin effect
Boettner B,
Van Aelst L

Genes Development
  16 (16): 2033-2038; Aug 2002  
[DOI] [Full Text]

Role of Rho family GTPases in epithelial morphogenesis
Van Aelst L,
Symons M

Genes Development
  16 (9): 1032-1054; May 2002  
[DOI] [Full Text] [PDF]

The role of Rho GTPases in disease development
Boettner B,
Van Aelst L

Gene
  286 (2): 155-74; Mar 20 2002  
[Abstract]
[DOI] [Full Text]

Using cDNA-representational difference analysis (cDNA-RDA) in combination with microarrays to identify Rac regulated genes
Schmitz AA,
Lucito R,
Van Aelst L
In:
GTPase Protocols: the Ras superfamily
(ed. ) : Humana Press; 2002. 189: 25-43  
[DOI] [Full Text]

CED-12/ELMO, a novel member of the crkII/dock180/rac pathway, is required for phagocytosis and cell migration
Gumienny TL,
Brugnera E,
Tosello-Trampont AC,
Kinchen JM,
Haney LB,
Nishiwaki K,
Walk SF,
Nemergut ME,
Macara IG,
Francis R,
Schedl T,
Qin Y,
Van Aelst L,
Hengartner MO,
Ravichandran KS

Cell
  107 (1): 27-41; Oct 2001  
[Abstract]
[Full Text]

p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl)
Di Cristofano A,
Niki M,
Zhao MM,
Karnell FG,
Clarkson B,
Pear WS,
Van Aelst L,
Pandolfi PP

Journal of Experimental Medicine
  194 (3): 275-284; Aug 2001   PMCID: PMC2193466
[Abstract]
[DOI] [Full Text] [PDF]

Phosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation
Zhao MM,
Schmitz AA,
Qin Y,
Di Cristofano A,
Pandolfi PP,
Van Aelst L

Journal of Experimental Medicine
  194 (3): 265-274; Aug 2001   PMCID: PMC2193463
[Abstract]
[Full Text] [PDF]

Ras and Rap1 interaction with AF-6 effector target
Boettner B,
Herrmann C,
Van Aelst L
In:
Regulators and Effectors of Small Gtpases, Pt F, Ras Family I
(ed. ) San Diego: Academic Press Inc; 2001. 332: 151-168  
[Full Text]

Role of p65(dok) in leukemogenesis by p210(bcr-abl)
Niki M,
Di Cristofano A,
Zhao M,
Karnell FG,
Clarkson B,
Pear WS,
Van Aelst L,
Pandolfi PP

Blood
  96 (11): 510A-510A; Nov 2000  


Rho GTPases: Signaling, migration, and invasion
Schmitz AA,
Govek EE,
Bottner B,
Van Aelst L

Experimental Cell Research
  261 (1): 1-12; Nov 2000  
[Abstract]
[DOI] [Full Text]

The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin
Boettner B,
Govek EE,
Cross J,
Van Aelst L

Proceedings of the National Academy of Sciences of the United States of America
  97 (16): 9064-9069; Aug 2000  
[Abstract]
[Full Text]

ADP-ribosylation factor 6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA
Boshans RL,
Szanto S,
van Aelst L,
DSouza-Schorey C

Molecular and Cellular Biology
  20 (10): 3685-3694; May 2000  
[Abstract]
[Full Text]

A role for the noncatalytic N terminus in the function of Cdc25, a Saccharomyces cerevisiae Ras-guanine nucleotide exchange factor
Chen RA,
Michaeli T,
Van Aelst L,
Ballester R

Genetics
  154 (4): 1473-1484; Apr 2000  
[Abstract]
[Full Text]

Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo
Li Z,
Van Aelst L,
Cline HT

Nature Neuroscience
  3 (3): 217-225; Mar 2000  
[Abstract]
[Full Text]

Rac and Cdc42 effectors
Boettner B,
Van Aelst L

Prog Mol Subcell Biol
  22 (0): 135-58; 1999  
[Full Text]

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
Lin AW,
Barradas M,
Stone JC,
van Aelst L,
Serrano M,
Lowe SW

Genes Dev
  12 (19): 3008-19; Oct 1 1998  
[Abstract]
[Full Text]

Signaling pathways in Ras-mediated tumorigenicity and metastasis
Webb CP,
Van Aelst L,
Wigler MH,
Woude GF

Proc Natl Acad Sci U S A
  95 (15): 8773-8; Jul 21 1998  
[Abstract]
[DOI] [Full Text]

Two-hybrid analysis of Ras-Raf interactions
Van Aelst L

Methods Mol Biol
  84 (0): 201-22; 1998  
[Full Text]

Rho GTPases and signaling networks
Van Aelst L,
DSouza-Schorey C

Genes Dev
  11 (18): 2295-322; Sep 15 1997  
[Full Text]

Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe
Barr MM,
Tu H,
Van Aelst L,
Wigler MH

Mol Cell Biol
  16 (10): 5597-603; Oct 1996  
[Abstract]
[Full Text]

Identification of a novel Rac1-interacting protein involved in membrane ruffling
Van Aelst L,
Joneson T,
Bar-Sagi D

Embo J
  15 (15): 3778-86; Aug 1 1996  
[Abstract]
[Full Text]

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation
Khosravi-Far R,
White MA,
Westwick JK,
Solski PA,
Chrzanowska-Wodnicka M,
Van Aelst L,
Wigler MH,
Der CJ

Mol Cell Biol
  16 (7): 3923-33; Jul 1996  
[Abstract]
[Full Text]

Two types of RAS mutants that dominantly interfere with activators of RAS
Jung V,
Wei W,
Ballester R,
Camonis J,
Mi S,
Van Aelst L,
Wigler MH,
Broek D

Mol Cell Biol
  14 (6): 3707-18; Jun 1994  
[Abstract]
[DOI] [Full Text]

Ras partners
Van Aelst L,
White M,
Wigler MH

Cold Spring Harbor Symposia on Quantitative Biology LIX: Molecular Genetics of Cancer
  59 181-186; 1994  


Complex formation between RAS and RAF and other protein kinases
Van Aelst L,
Barr M,
Marcus S,
Polverino A,
Wigler MH

Proc Natl Acad Sci U S A
  90 (13): 6213-7; Jul 1 1993  
[Abstract]
[DOI] [Full Text]

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
Chardin P,
Camonis JH,
Gale NW,
van Aelst L,
Schlessinger J,
Wigler MH,
Bar-Sagi D

Science
  260 (5112): 1338-1343; May 28 1993  
[Abstract]
[DOI] [Full Text]


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