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35 Article(s) on File
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In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer
Rudalska R,
Dauch D,
Longerich T,
McJunkin K,
Wuestefeld T,
Kang TW,
Hohmeyer A,
Pesic M,
Leibold J,
von Thun A,
Schirmacher P,
Zuber J,
Weiss KH,
Powers S,
Malek NP,
Eilers M,
Sipos B,
Lowe SW,
Geffers R,
Laufer S,
Zender L

Nature Medicine
  20 (10): 1138-1146; Oct 2014   NLM
[Abstract]
[DOI] [Full Text]

Development of siRNA payloads to target KRAS-mutant cancer
Yuan TL,
Fellmann C,
Lee CS,
Ritchie CD,
Thapar V,
Lee LC,
Hsu DJ,
Grace D,
Carver JO,
Zuber J,
Luo J,
McCormick F,
Lowe SW

Cancer Discovery
  4 (10): 1182; Oct 1 2014   Nlm
[Abstract]
[DOI] [Full Text]

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma
Huang CH,
Lujambio A,
Zuber J,
Tschaharganeh DF,
Doran MG,
Evans MJ,
Kitzing T,
Zhu N,
de Stanchina E,
Sawyers CL,
Armstrong SA,
Lewis JS,
Sherr CJ,
Lowe SW

Genes and Development
  28 (16): 1800-1814; Aug 15 2014   NLM
[Abstract]
[DOI] [Full Text]

Reversible Suppression of Cyclooxygenase 2 (COX-2) Expression In Vivo by Inducible RNA Interference
Zaiss AK,
Zuber J,
Chu C,
Machado HB,
Jiao J,
Catapang AB,
Ishikawa TO,
Gil JS,
Lowe SW,
Herschman HR

PLoS One
  9 (7): e101263; Jul 2 2014   Nlm
[Abstract]
[DOI] [Full Text]

THE EPIGENETIC READER BRD4 SERVES AS A NOVEL MARKER AND TARGET IN AGGRESSIVE SYSTEMIC MASTOCYTOSIS AND MAST CELL LEUKEMIA
Wedeh G,
Cerny-Reiterer S,
Hadzijusufovic E,
Herrmann H,
Blatt K,
Eisenwort G,
Hoermann G,
Sperr WR,
Muellauer L,
Vakoc CR,
Bradner JE,
Horny H,
Zuber J,
Arock M,
Valent P

Haematologica
  99 (0): 514-515; Jun 2014   ThomsonReuters
[Full Text]

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia
Chen C,
Liu Y,
Rappaport AR,
Kitzing T,
Schultz N,
Zhao Z,
Shroff AS,
Dickins RA,
Vakoc CR,
Bradner JE,
Stock W,
LeBeau MM,
Shannon KM,
Kogan S,
Zuber J,
Lowe SW

Cancer Cell
  25 (5): 652-65; May 1 2014   Nlm
[Abstract]
[DOI] [Full Text]

MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
Chen C,
Liu Y,
Rappaport AR,
Kitzing T,
Schultz N,
Zhao Z,
Shroff AS,
Dickins RA,
Vakoc CR,
Bradner JE,
Stock W,
Lebeau MM,
Shannon KM,
Kogan S,
Zuber J,
Lowe SW

Cancer Cell
  25 (5): 652-665; Apr 30 2014   NLM
[Abstract]
[DOI] [Full Text]

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation
Shi J,
Whyte WA,
Zepeda-Mendoza CJ,
Milazzo JP,
Shen C,
Roe JS,
Minder JL,
Mercan F,
Wang E,
Eckersley-Maslin MA,
Campbell AE,
Kawaoka S,
Shareef S,
Zhu Z,
Kendall J,
Muhar M,
Haslinger C,
Yu M,
Roeder RG,
Wigler MA,
Blobel GA,
Zuber J,
Spector DL,
Young RA,
Vakoc CR

Genes Dev
  27 (24): 264-273 ; Nov 27 2013   NLM
[Abstract]
[DOI] [Full Text]

The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia
Shi J,
Wang E,
Zuber J,
Rappaport A,
Taylor M,
Johns C,
Lowe SW,
Vakoc CR

Oncogene
  32 (7): 930-938; Feb 2 2013   NLM
[Abstract]
[DOI] [Full Text]

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML)
Herrmann H,
Blatt K,
Shi J,
Gleixner KV,
Cerny-Reiterer S,
Müllauer L,
Vakoc CR,
Sperr WR,
Horny HP,
Bradner JE,
Zuber J,
Valent P

Oncotarget
  3 (12): 1588-1599; Dec 2012  
[Abstract]
[Full Text]

Next Generation RNAi Mouse Models for Drug Discovery and Toxicology Assessment
Premsrirut P,
Fellmann C,
Dow L,
Lowe S,
Zuber J,
Hannon G

European Journal of Cancer
  48 (0): 16-16; Nov 6 2012  
[Full Text]

Proffered Paper: Next Generation RNAi Mouse Models for Drug Discovery and Toxicology Assessment
Premsrirut P,
Fellmann C,
Hannon GJ,
Lowe SW,
Zuber J,
Elledge S

European Journal of Cancer
  48 (0): S14-S14; Jul 2012  
[Full Text]

An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model
Bergerson RJ,
Collier LS,
Sarver AL,
Been RA,
Lugthart S,
Diers MD,
Zuber J,
Rappaport AR,
Nixon MJ,
Silverstein KA,
Fan DH,
Lamblin AF,
Wolff L,
Kersey JH,
Delwel R,
Lowe SW,
OSullivan MG,
Kogan SC,
Adams DJ,
Largaespada DA

Blood
  119 (19): 4512-4523; May 10 2012  
[Abstract]
[DOI] [Full Text]

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions
Xue W,
Kitzing T,
Roessler S,
Zuber J,
Krasnitz A,
Schultz N,
Revill K,
Weissmueller S,
Rappaport AR,
Simon J,
Zhang J,
Luo WJ,
Hicks J,
Zender L,
Wang XW,
Powers S,
Wigler M,
Lowe SW

Proceedings of the National Academy of Sciences of the United States of America
  109 (21): 8212-8217; May 2012  
[Abstract]
[DOI] [Full Text]

A pipeline for the generation of shRNA transgenic mice
Dow LE,
Premsrirut PK,
Zuber J,
Fellmann C,
McJunkin K,
Miething C,
Park Y,
Dickins RA,
Hannon GJ,
Lowe SW

Nat Protoc
  7 (2): 374-93; Feb 2 2012   NLM
[Abstract]
[DOI] [Full Text]

Anti-apoptotic mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
Glaser SP,
Lee EF,
Trounson E,
Bouillet P,
Wei A,
Fairlie WD,
Izon DJ,
Zuber J,
Rappaport AR,
Herold MJ,
Alexander WS,
Lowe SW,
Robb L,
Strasser A

Genes and Development
  26 (2): 120-125; Jan 2012  
[Abstract]
[DOI] [Full Text]

Small-Molecule Inhibition of BRD4 Is a Novel Promising Approach to Therapeutically Target Leukemia Stem Cells in AML
Herrmann H,
Blatt K,
Shi JW,
Rappaport AR,
Gleixner KV,
Cerny-Reiterer S,
Peter B,
Wang E,
Sperr WR,
Bradner JE,
Lowe SW,
Vakoc CR,
Zuber J,
Valent P

Blood
  118 (21): 1487-1487; Nov 2011  
[Full Text]

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
Zuber J,
Shi J,
Wang E,
Rappaport AR,
Herrmann H,
Sison EA,
Magoon D,
Qi J,
Blatt K,
Wunderlich M,
Taylor MJ,
Johns C,
Chicas A,
Mulloy JC,
Kogan SC,
Brown P,
Valent P,
Bradner JE,
Lowe SW,
Vakoc CR

Nature
  478 (7370): 524-528; Aug 3 2011   NLM
[Abstract]
[DOI]

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
Zuber J,
Rappaport AR,
Luo W,
Wang E,
Chen C,
Vaseva AV,
Shi J,
Weissmueller S,
Fellman C,
Taylor MJ,
Weissenboeck M,
Graeber TG,
Kogan SC,
Vakoc CR,
Lowe SW

Genes Dev
  25 (15): 1628-1640; Aug 1 2011  
[Abstract]
[DOI]

Reversible suppression of an essential gene in adult mice using transgenic RNA interference
McJunkin K,
Mazurek A,
Premsrirut PK,
Zuber J,
Dow LE,
Simon J,
Stillman B,
Lowe SW

Proc Natl Acad Sci U S A
  108 (17): 7113-7118; Apr 26 2011   NLM PMC3084121
[Abstract]
[DOI]

The Flt3 Internal Tandem Duplication Alters Chemotherapy Response In Vitro and In Vivo in a p53-Dependent Manner
Pardee TS,
Zuber J,
Lowe SW

Experimental Hematology
  39 (4): 473-485; Apr 2011   PMC3062750
[Abstract]
[DOI] [Full Text] [PDF]

A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference
Premsrirut PK,
Dow LE,
Kim SY,
Camiolo M,
Malone CD,
Miething C,
Scuoppo C,
Zuber J,
Dickins RA,
Kogan S,
Shroyer K,
Sordella R,
Hannon GJ,
Lowe SW

Cell
  145 (1): 145-158; Mar 31 2011   Elsevier
[Abstract]
[DOI]

Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay
Fellmann C,
Zuber J,
McJunkin K,
Chang K,
Malone CD,
Dickins R,
Xu Q,
Hengartner M,
Elledge SJ,
Hannon GJ,
Lowe SW

Molecular Cell
  41 (6): 733-746; Mar 18 2011   Array
[Abstract]
[DOI]

Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi
Zuber J,
McJunkin K,
Fellmann C,
Dow L,
Taylor MJ,
Hannon GJ,
Lowe SW

Nature Biotechnology
  29 (1): 79-85; Jan 2011  
[Abstract]
[DOI] [Full Text] [PDF]

An RNA1 Screen Reveals a Pattern of Addiction to Epigenetic Pathways That Distinguishes MLL AF9 Leukemia From Normal Hematopoietic Cells
Vakoc CR,
Zuber J,
Lowe S,
Wang E,
Rappaport AR,
Shi JW

Blood
  116 (21): 35-35; Nov 2010   ISI


p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal
Zhao Z,
Zuber J,
Diaz-Flores E,
Lintault L,
Kogan SC,
Shannon K,
Lowe SW

Genes Dev
  24 (13): 1389-402; Jul 1 2010   PMCID: PMC2895198
[Abstract]
[DOI] [Full Text] [PDF]

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia
Mavrakis KJ,
Wolfe AL,
Oricchio E,
Palomero T,
de Keersmaecker K,
McJunkin K,
Zuber J,
James T,
Chang K,
Khan AA,
Leslie CS,
Parker JS,
Paddison PJ,
Tam W,
Ferrando A,
Wendel HG

Nature Cell Biology
  12 (4): 372-U159; Apr 2010   PMCID: PMC2989719
[Abstract]
[DOI] [Full Text] [PDF]

A Reconfigured Pattern of MLL Occupancy within Mitotic Chromatin Promotes Rapid Transcriptional Reactivation Following Mitotic Exit
Blobel GA,
Kadauke S,
Wang E,
Lau AW,
Zuber J,
Chou MM,
Vakoc CR

Molecular Cell
  36 (6): 970-983; Dec 24 2009   PMC2818742
[Abstract]
[DOI] [Full Text]

TAp63 induces senescence and suppresses tumorigenesis in vivo
Guo X,
Keyes WM,
Papazoglu C,
Zuber J,
Li W,
Lowe SW,
Vogel H,
Mills AA

Nat Cell Biol
  11 (12): 1451–1457; Dec 2009   PMCID: PMC2920298
[Abstract]
[DOI] [Full Text] [PDF]

The Flt3 ITD Accelerates An Already Established Myeloid Leukemia and Alters Chemotherapy Response In Vitro and In Vivo in a p53 Dependent Manner
Pardee T,
Zuber J,
Lowe SW

Blood
  114 (22): 685-685; Nov 2009  
[Abstract]
[Full Text]

Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model
Bric A,
Miething C,
Bialucha CU,
Scuoppo C,
Zender L,
Krasnitz A,
Xuan Z,
Zuber J,
Wigler MH,
Hicks JB,
McCombie RW,
Hemann MT,
Hannon GJ,
Powers S,
Lowe SW

Cancer Cell
  16 (4): 324-35; Oct 6 2009   PMC2829755
[Abstract]
[DOI] [Full Text] [PDF]

Effects of the Flt3 ITD on response to chemotherapy in a murine model of acute myeloid leukemia
Pardee TS,
Zuber J,
Lowe SW

Journal of Clinical Oncology
  27 (15): 7060; May 20 2009  
[Full Text]

Mouse models of human AML accurately predict chemotherapy response
Zuber J,
Radtke I,
Pardee TS,
Zhao Z,
Rappaport AR,
Luo W,
McCurrach ME,
Yang MM,
Dolan ME,
Kogan SC,
Downing JR,
Lowe SW

Genes Dev
  23 (7): 877-89; Apr 1 2009   PMCID: PMC2666344
[Abstract]
[DOI]

Conditional Regulation of Tumor Suppressor Genes in Vivo Using Rna Interference
Premsrirut PK,
Miething C,
Zuber J,
Yong KS,
Hannon GJ,
Lowe SW

Journal of Investigative Medicine
  57 (3): 82; Mar 2009  
[Full Text] [PDF]

An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer
Zender L,
Xue W,
Zuber J,
Semighini CP,
Krasnitz A,
Ma B,
Zender P,
Kubicka S,
Luk JM,
Schirmacher P,
McCombie WR,
Wigler MH,
Hicks JB,
Hannon GJ,
Powers S,
Lowe SW

Cell
  135 (5): 852-864; Nov 28 2008   PMC2990916
[Abstract]
[DOI] [Full Text] [PDF]


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