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25 Article(s) on File
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In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer
Rudalska R,
Dauch D,
Longerich T,
McJunkin K,
Wuestefeld T,
Kang TW,
Hohmeyer A,
Pesic M,
Leibold J,
von Thun A,
Schirmacher P,
Zuber J,
Weiss KH,
Powers S,
Malek NP,
Eilers M,
Sipos B,
Lowe SW,
Geffers R,
Laufer S,
Zender L

Nature Medicine
  20 (10): 1138-1146; Oct 2014   NLM
[Abstract]
[DOI] [Full Text]

p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer
Tschaharganeh DF,
Xue W,
Calvisi DF,
Evert M,
Michurina TV,
Dow LE,
Banito A,
Katz SF,
Kastenhuber ER,
Weissmueller S,
Huang CH,
Lechel A,
Andersen JB,
Capper D,
Zender L,
Longerich T,
Enikolopov G,
Lowe SW

Cell
  158 (3): 579-92; Jul 31 2014   Nlm
[Abstract]
[DOI] [Full Text]

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions
Xue W,
Kitzing T,
Roessler S,
Zuber J,
Krasnitz A,
Schultz N,
Revill K,
Weissmueller S,
Rappaport AR,
Simon J,
Zhang J,
Luo WJ,
Hicks J,
Zender L,
Wang XW,
Powers S,
Wigler M,
Lowe SW

Proceedings of the National Academy of Sciences of the United States of America
  109 (21): 8212-8217; May 2012  
[Abstract]
[DOI] [Full Text]

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening
Sawey ET,
Chanrion M,
Cai C,
Wu G,
Zhang J,
Zender L,
Zhao A,
Busuttil RW,
Yee H,
Stein LD,
French DM,
Finn RS,
Lowe SW,
Powers S

Cancer Cell
  19 (3): 347-358; Mar 8 2011   Elsevier PMC3061399
[Abstract]
[DOI]

AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma
Xu MZ,
Chan SW,
Liu AM,
Wong KF,
Fan ST,
Chen J,
Poon RT,
Zender L,
Lowe SW,
Hong W,
Luk JM

Oncogene
  30 (10): 1229-1240; Mar 2011   ISI
[Abstract]
[DOI]

Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma
Liu LX,
Lee NP,
Chan VW,
Xue W,
Zender L,
Zhang C,
Mao M,
Dai H,
Wang XL,
Xu MZ,
Lee K,
Ng IO,
Chen ,
Kung H,
Lowe SW,
Poon RT,
Wang JH,
Luk JM

Hepatology
  50 (5): 1453-1463; Nov 2009  
[Abstract]
[DOI] [Full Text]

Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model
Bric A,
Miething C,
Bialucha CU,
Scuoppo C,
Zender L,
Krasnitz A,
Xuan Z,
Zuber J,
Wigler MH,
Hicks JB,
McCombie RW,
Hemann MT,
Hannon GJ,
Powers S,
Lowe SW

Cancer Cell
  16 (4): 324-35; Oct 6 2009   PMC2829755
[Abstract]
[DOI] [Full Text] [PDF]

Yes-Associated Protein Is an Independent Prognostic Marker in Hepatocellular Carcinoma
Xu MZ,
Yao TJ,
Lee NP,
Ng IO,
Chan YT,
Zender L,
Lowe SW,
Poon RT,
Luk JM

Cancer
  115 (19): 4576-4585; Oct 2009   PMC2811690
[Abstract]
[DOI] [Full Text] [PDF]

Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms
Laska MJ,
Lowe SW,
Zender L,
Hearn SA,
Vogel U,
Jensen UB,
Bric A,
Nexo BA

Mol Carcinog
  48 (9): 832-42; Sep 2009  
[Abstract]
[DOI] [Full Text]

MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), Amplified on Chromosome 9, Collaborate with p53 Deficiency in Mouse Osteosarcoma Progression
Ma O,
Cai WW,
Zender L,
Dayaram T,
Shen JH,
Herron AJ,
Lowe SW,
Man TK,
Lau CC,
Donehower LA

Cancer Res
  69 (6): 2559-2567; Mar 15 2009   PMCID: PMC2663905
[Abstract]
[DOI] [Full Text] [PDF]

An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer
Zender L,
Xue W,
Zuber J,
Semighini CP,
Krasnitz A,
Ma B,
Zender P,
Kubicka S,
Luk JM,
Schirmacher P,
McCombie WR,
Wigler MH,
Hicks JB,
Hannon GJ,
Powers S,
Lowe SW

Cell
  135 (5): 852-864; Nov 28 2008   PMC2990916
[Abstract]
[DOI] [Full Text] [PDF]

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis
Gyrd-Hansen M,
Darding M,
Miasari M,
Santoro MM,
Zender L,
Xue W,
Tenev T,
da Fonseca PC,
Zvelebil M,
Bujnicki JM,
Lowe SW,
Silke J,
Meier P

Nat Cell Biol
  10 (11): 1309-17; Nov 2008  
[Abstract]
[DOI] [Full Text] [PDF]

Senescence of activated stellate cells limits liver fibrosis
Krizhanovsky V,
Yon M,
Dickens RA,
Hearn SA,
Simon J,
Ma B,
Miething C,
Zender L,
Lowe SW

Cell
  134 (4): 657-667 ; Aug 22 2008  
[DOI] [Full Text] [PDF]

Topoisomerase levels determine chemotherapy response in vitro and in vivo
Burgess DJ,
Doles J,
Zender L,
Xue W,
Ma B,
McCombie WR,
Hannon GJ,
Lowe SW,
Hemann MT

Proc Natl Acad Sci U S A
  105 (25): 9053-9058; Jul 1 2008   PMCID: PMC2435590
[Abstract]
[DOI] [Full Text] [PDF]

DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma
Xue W,
Krasnitz A,
Lucito R,
Sordella R,
Van Aelst L,
Cordon-Cardo C,
Singer S,
Kuehnel F,
Wigler MH,
Powers S,
Zender L,
Lowe SW

Genes Dev
  22 (11): 1439-44; Jun 1 2008   PMCID: PMC2418580
[Abstract]
[DOI] [Full Text] [PDF]

Integrative oncogenomic approaches for accelerated cancer-gene discovery
Zender L,
Lowe SW

Curr Opin Oncol
  20 (1): 72-6; Jan 2008  
[Abstract]
[DOI] [Full Text]

Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology
Krizhanovsky V,
Xue W,
Zender L,
Yon M,
Hernando E,
Lowe SW

Cold Spring Harb Symp Quant Biol
  73 (0): 513-22; 2008  
[Abstract]
[DOI] [Full Text] [PDF]

Tissue-specific and reversible RNA interference in transgenic mice
Dickins RA,
McJunkin K,
Hernando E,
Premsrirut PK,
Krizhanovsky V,
Burgess DJ,
Kim SY,
Cordon-Cardo C,
Zender L,
Hannon GJ,
Lowe SW

Nat Genet
  39 (7): 914 - 921; Jul 2007  
[Abstract]
[DOI] [Full Text] [PDF]

A microRNA component of the p53 tumour suppressor network
He L,
He X,
Lim LP,
De Stanchina E,
Xuan Z,
Liang Y,
Xue W,
Zender L,
Magnus J,
Ridzon D,
Jackson AL,
Linsley PS,
Chen C,
Lowe SW,
Cleary MA,
Hannon GJ

Nature
  447 (7148): 1130-4; Jun 28 2007  
[Abstract]
[DOI] [Full Text] [PDF]

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue W,
Zender L,
Miething C,
Dickins RA,
Hernando E,
Krizhanovsky V,
Cordon-Cardo C,
Lowe SW

Nature
  445 (7128): 656-660; Feb 2007  
[Abstract]
[DOI] [Full Text] [PDF]

Suppression of apoptosis in the liver by systemic and local delivery of small-interfering RNAs
Zender L,
Kubicka S

Methods Mol Biol
  361 (0): 217-26; 2007  
[Abstract]
[DOI] [Full Text]

P53 restoration in liver carcinomas induces cellular senescence and tumor clearance through an innate immune response
Zender L,
Xue W,
Cordon-Cardo C,
Lowe SW

Hepatology
  44 (4): 694A-695A; Oct 2006  
[DOI] [Full Text]

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
Zender L,
Spector MS,
Xue W,
Flemming P,
Cordon-Cardo C,
Silke J,
Fan ST,
Luk JM,
Wigler MH,
Hannon GJ,
Mu D,
Lucito R,
Powers S,
Lowe SW

Cell
  125 (7): 1253-67; Jun 30 2006  
[Abstract]
[DOI] [Full Text] [PDF]

Representational oligonucleotide microarray (ROMA) identifies cIAP1/cIAP2 as candidate oncogenes in mouse and human hepatocarcinogenesis-validation of cIAP1 as a therapeutic target in liver cancer in a new mouse model of hepatocellular carcinoma
Zender L,
Spector MS,
Xue W,
Flemming P,
Mu D,
Cordon-Cardo C,
Powers S,
Hannon GJ,
Lucito R,
Lowe SW

Hepatology
  42 (4): 244A-244A; Oct 2005  
[Full Text]

Generation and Analysis of Genetically Defined Liver Carcinomas Derived from Bipotential Liver Progenitors
Zender L,
Xue W,
Cordon-Cardo C,
Hannon GJ,
Lucito R,
Powers S,
Flemming P,
Spector MS,
Lowe SW

Cold Spring Harbor Symposia on Quantitative Biology VXX: Molecular approaches to controlling cancer
  70 251-261; 2005  
[Abstract]
[DOI] [Full Text] [PDF]


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