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194 Article(s) on File
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Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism
Horev G,
Ellegood J,
Lerch JP,
Son YE,
Muthuswamy L,
Vogel H,
Krieger AM,
Buja A,
Henkelman RM,
Wigler MH,
Mills AA

Proc Natl Acad Sci U S A
  108 (41): 17076-17081 ; Oct 11 2011   NLM
[Abstract]
[DOI]

Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum Disorders
Levy D,
Ronemus M,
Yamrom B,
Lee YH,
Leotta A,
Kendall JT,
Marks S,
Lakshmi B,
Pai D,
Ye K,
Buja A,
Krieger A,
Yoon S,
Troge JE,
Rodgers ,
Iossifov I,
Wigler MH

Neuron
  70 (5): 886-897; Jun 8 2011  
[Abstract]
[DOI]

Rare De Novo Variants Associated with Autism Implicate a Large Functional Network of Genes Involved in Formation and Function of Synapses
Gilman S,
Iossifov I,
Levy D,
Ronemus M,
Wigler MH,
Vitkup D

Neuron
  70 (5): 898-907; Jun 8 2011  
[Abstract]
[DOI]

DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables
Kamalakaran S,
Varadan V,
Giercksky Russnes HE,
Levy D,
Kendall JT,
Janevski A,
Riggs M,
Banerjee N,
Synnestvedt M,
Schlichting E,
KÃ¥resen R,
Shama Prasada K,
Rotti H,
Rao R,
Rao L,
Eric Tang MH,
Satyamoorthy K,
Lucito R,
Wigler MH,
Dimitrova N,
Naume B,
Borresen-Dale AL,
Hicks JB

Molecular Oncology
  5 (1): 77-92; Feb 2011  
[Abstract]
[DOI] [Full Text] [PDF]

Tumour evolution inferred by single-cell sequencing
Navin NE,
Kendall JT,
Troge JE,
Andrews P,
Rodgers ,
McIndoo J,
Cook K,
Stepansky ,
Levy D,
Esposito D,
Muthuswamy L,
Krasnitz A,
McCombie WR,
Hicks JB,
Wigler MH

Nature
  (0): 2011   Elsevier
[Abstract]
[DOI] [Full Text]

Genomic architecture characterizes tumor progression paths and fate in breast cancer patients
Russnes HG,
Vollan HK,
Lingjærde OC,
Krasnitz A,
Lundin P,
Naume B,
Sørlie T,
Borgen E,
Rye IH,
Langerød A,
Chin SF,
Teschendorff AE,
Stephens PJ,
Månér S,
Schlichting E,
Baumbusch LO,
Kåresen R,
Stratton MP,
Wigler MH,
Caldas C,
Zetterberg A,
Hicks JB,
Børresen-Dale AL

Science Translational Medicine
  2 (38): Jun 30 2010  
[Abstract]
[DOI] [Full Text] [PDF]

Tracing Tumor Lineage and Progression through Genomic Copy Number Profiling at the Single Cell Level
Hicks JB,
Navin NE,
Kendall JT,
Levy D,
Wigler MH

Annals of Oncology
  21 (0): 96O; May 2010  
[Full Text]

Inferring tumor progression from genomic heterogeneity
Navin NE,
Krasnitz A,
Rodgers L,
Cook K,
Meth JL,
Kendall JT,
Riggs M,
Eberling Y,
Troge JE,
Grubor V,
Levy D,
Lundin P,
Månér S,
Zetterberg A,
Hicks JB,
Wigler MH

Genome Research
  20 (1): 68-80; Jan 2010   PMCID: PMC2798832
[Abstract]
[DOI] [Full Text] [PDF]

Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model
Bric A,
Miething C,
Bialucha CU,
Scuoppo C,
Zender L,
Krasnitz A,
Xuan Z,
Zuber J,
Wigler MH,
Hicks JB,
McCombie RW,
Hemann MT,
Hannon GJ,
Powers S,
Lowe SW

Cancer Cell
  16 (4): 324-35; Oct 6 2009   PMC2829755
[Abstract]
[DOI] [Full Text] [PDF]

High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing Dup removed 04/2012
Hodges E,
Smith AD,
Kendall JT,
Xuan Z,
Ravi K,
Rooks M,
Zhang MQ,
Ye K,
Bhattacharjee A,
Brizuela L,
McCombie WR,
Wigler MH,
Hannon GJ,
Hicks JB

Genome Res
  19 (9): 1593-1605; Sep 2009   PMCID: PMC2752124
[Abstract]
[DOI] [Full Text] [PDF]

High resolution microarray copy number analysis (array CGH) suggests that determination of HER2 amplification by FISH (FISH plus ) is inaccurate in human breast cancer specimens that are HER2 2+by immunohistochemistry (IHC2+)
McArthur HL,
Brogi E,
Patil S,
Wigler MH,
Norton L,
Hicks JB,
Hudis CA

Ejc Supplements
  7 (2): 88-88; Sep 2009  
[DOI] [Full Text] [PDF]

Topo2a and Her2 Co-Amplification Is Uncommon by High Resolution Representational Oligonucleotide Microarray Analysis (Roma) in Human Breast Cancer
Hicks JB,
McArthur H,
Tan LK,
Patil S,
Wigler MH,
Hudis C,
Norton L

Annals of Oncology
  20 (0): 22-23; May 2009  
[Full Text]

Molecular subclassification of breast carcinomas based on aCGH reveals two major groups of tumors with common genomic, transcriptomic and clinicopathological characteristics
Russnes HG,
Vollan HK,
Sorlie T,
Krasnitz A,
Zetterberg A,
Naume B,
Borgen E,
Nesland JM,
Wigler MH,
Borresen-Dale AL,
Hicks JB

Apmis
  117 (3): 238-239; Mar 2009  
[Full Text]

Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA)
Grubor V,
Krasnitz A,
Troge JE,
Meth JL,
Lakshmi B,
Kendall JT,
Yamrom B,
Alex G,
Pai D,
Navin NE,
Hufnagel LA,
Lee YH,
Cook K,
Allen SL,
Rai KR,
Damle RN,
Calissano C,
Chiorazzi N,
Wigler MH,
Esposito D

Blood
  113 (6): 1294-1303; Feb 5 2009  
[Abstract]
[DOI] [Full Text] [PDF]

High resolution representational oligonucleotide microarray analysis (ROMA) suggests that TOPO2 and HER2 co-amplification is uncommon in human breast cancer
McArthur HL,
Tan LK,
Patil S,
Wigler MH,
Hudis CA,
Hicks JB,
Norton L

Cancer Res
  69 (2): 163S-163S; Jan 15 2009  
[DOI] [Full Text]

Classification method for microarray probe selection using sequence, thermodynamics and secondary structure parameters
Gupta L,
Kumar S,
Singh R,
Shaik R,
Dimitrova N,
Gorthi A,
Lakshmi B,
Pai D,
Kamalakaran S,
Zhao X,
Wigler MH

2008 19th International Conference on Pattern Recognition
  1; Dec 2008  
[Abstract]
[DOI] [Full Text]

An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer
Zender L,
Xue W,
Zuber J,
Semighini CP,
Krasnitz A,
Ma B,
Zender P,
Kubicka S,
Luk JM,
Schirmacher P,
McCombie WR,
Wigler MH,
Hicks JB,
Hannon GJ,
Powers S,
Lowe SW

Cell
  135 (5): 852-864; Nov 28 2008   PMC2990916
[Abstract]
[DOI] [Full Text] [PDF]

High-Resolution Array-Based Comparative Genome Hybridization (CGH) Identifies Novel and Recurrent Regions in CLL
Grubor V,
Krasnitz A,
Troge JE,
Meth JL,
Lakshmi B,
Kendall JT,
Yamrom B,
Alex G,
Pai D,
Navin NE,
Hufnagel LA,
Lee YH,
Cook K,
Allen SL,
Rai KR,
Damle R,
Calissano C,
Chiorazzi N,
Wigler MH,
Esposito D

Blood
  112 (11): 717-717; Nov 2008  
[Abstract]
[Full Text]

Molecular subclassification of breast carcinomas based on aCGH, gene expression, IHC and ploidy - relevance for clinical outcome
Russnes HG,
Sorlie T,
Krasnitz A,
Zetterberg A,
Naume B,
Borgen E,
Nesland JM,
Wigler MH,
Borresen-Dale AL,
Hicks JB

Ejc Supplements
  6 (9): 9-9; Jul 2008  
[DOI]

DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma
Xue W,
Krasnitz A,
Lucito R,
Sordella R,
Van Aelst L,
Cordon-Cardo C,
Singer S,
Kuehnel F,
Wigler MH,
Powers S,
Zender L,
Lowe SW

Genes Dev
  22 (11): 1439-44; Jun 1 2008   PMCID: PMC2418580
[Abstract]
[DOI] [Full Text] [PDF]

Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene
Alarcon M,
Abrahams BS,
Stone JL,
Duvall JA,
Perederiy JV,
Bomar JM,
Sebat J,
Wigler MH,
Martin CL,
Ledbetter DH,
Nelson SF,
Cantor RM,
Geschwind DH

Am J Hum Genet
  82 (1): 150-159; Jan 2008   PMCID: PMC2253955
[Abstract]
[DOI] [Full Text] [PDF]

Recurrent DNA copy number variation in the laboratory mouse
Egan CM,
Sridhar S,
Wigler MH,
Hall IM

Nat Genet
  39 (11): 1384-9; Nov 2007  
[Abstract]
[DOI] [Full Text] [PDF]

Copy-Number Variants in Patients with a Strong Family History of Pancreatic Cancer
Lucito R,
Suresh S,
Walter K,
Pandey A,
Lakshmi B,
Krasnitz A,
Sebat J,
Wigler MH,
Klein AP,
Brune K,
Palmisano E,
Maitra A,
Goggins M,
Hruban RH

Cancer Biol Ther
  6 (10): 1592-9; Oct 2007  
[Abstract]
[DOI] [Full Text]

A unified genetic theory for sporadic and inherited autism
Zhao X,
Leotta A,
Kustanovich V,
Lajonchere C,
Geschwind DH,
Law K,
Law P,
Qiu S,
Lord C,
Sebat J,
Ye K,
Wigler MH

Proc Natl Acad Sci U S A
  104 (31): 12831-12836; Jul 31 2007  
[Abstract]
[DOI] [Full Text] [PDF]

Strong Association of De Novo Copy Number Mutations with Autism
Sebat J,
Lakshmi B,
Malhotra D,
Troge JE,
Lese-Martin C,
Walsh T,
Yamrom B,
Yoon S,
Krasnitz A,
Kendall JT,
Leotta A,
Pai D,
Zhang R,
Lee YH,
Hicks JB,
Spence SJ,
Lee AT,
Puura K,
Lehtimaki T,
Ledbetter D,
Gregersen PK,
Bregman J,
Sutcliffe JS,
Jobanputra V,
Chung W,
Warburton D,
King MC,
Skuse D,
Geschwind DH,
Gilliam TC,
Ye K,
Wigler MH

Science
  316 (5823): 445-449; April 20 2007  
[Abstract]
[DOI] [Full Text] [PDF]

High-resolution analysis of genome copy number variation in autism
Sebat J,
Lakshmi B,
Troge J,
Martin C,
Spence S,
Ledbetter D,
Gilliam TC,
Ye K,
Geschwind D,
Sutcliffe J,
Wigler MH

International Journal of Developmental Neuroscience
  24 (8): 474; Dec 2006  
[DOI] [Full Text]

Identification of alterations in DNA copy number in host stromal cells during tumor progression
Pelham RJ,
Rodgers L,
Hall IM,
Lucito R,
Nguyen KC,
Navin NE,
Hicks JB,
Mu D,
Powers S,
Wigler MH,
Botstein D

Proc Natl Acad Sci U S A
  103 (52): 19848-19853; Dec 2006  
[Abstract]
[DOI] [Full Text]

Novel patterns of genome rearrangement and their association with survival in breast cancer
Hicks JB,
Krasnitz A,
Lakshmi B,
Navin NE,
Riggs M,
Leibu E,
Esposito D,
Alexander J,
Troge JE,
Grubor V,
Yoon S,
Wigler MH,
Ye K,
Borresen-Dale AL,
Naume B,
Schlicting E,
Norton L,
Hagerstrom T,
Skoog L,
Auer G,
Månér S,
Lundin P,
Zetterberg A

Genome Res
  16 (12): 1465-79; Dec 2006  
[Abstract]
[DOI] [Full Text] [PDF]

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
Zender L,
Spector MS,
Xue W,
Flemming P,
Cordon-Cardo C,
Silke J,
Fan ST,
Luk JM,
Wigler MH,
Hannon GJ,
Mu D,
Lucito R,
Powers S,
Lowe SW

Cell
  125 (7): 1253-67; Jun 30 2006  
[Abstract]
[DOI] [Full Text] [PDF]

Validation of S. Pombe sequence assembly by microarray hybridization
West J,
Healy J,
Wigler MH,
Casey W,
Mishra B

J Comput Biol
  13 (1): 1-20; Jan-Feb 2006  
[Abstract]
[DOI] [Full Text] [PDF]

Assessment of schizophrenia genomes for DNA copy number alterations
Sachs NA,
Holmes SE,
Cowell JK,
Conroy J,
Nowak NJ,
McQuaid D,
Rossi MR,
Gaile DP,
Christian SL,
Wigler MH,
Sebat J,
Ross CA,
DeLisi LE,
Margolis RL

American Journal of Medical Genetics Part B-Neuropsychiatric Genetics
  138B (1): 90-91; Sep 2005  
[Full Text]

Application of ROMA (representational oligonucleotide microarray analysis) to patients with cytogenetic rearrangements
Jobanputra V,
Sebat J,
Troge J,
Chung W,
Anyane-Yeboa K,
Wigler MH,
Warburton D

Genetics in Medicine
  7 (2): 111-118; Feb 2005  
[Abstract]
[Full Text]

High-resolution ROMA CGH and FISH analysis of aneuploid and diploid breast tumors
Hicks JB,
Muthuswamy L,
Krasnitz A,
Navin NE,
Riggs M,
Grubor V,
Esposito D,
Alexander J,
Troge JE,
Wigler MH,
Maner S,
Lundin P,
Zetterberg A

Cold Spring Harbor Symposia on Quantitative Biology VXX: Molecular approaches to controlling cancer
  70 51-63; 2005  
[Abstract]
[DOI] [Full Text]

A versatile statistical analysis algorithm to detect genome copy number variation
Daruwala RS,
Rudra A,
Ostrer H,
Lucito R,
Wigler MH,
Mishra B

Proceedings of the National Academy of Sciences of the United States of America
  101 (46): 16292-16297; Nov 2004  
[Abstract]
[DOI] [Full Text]

Circular binary segmentation for the analysis of array-based DNA copy number data
Olshen AB,
Venkatraman ES,
Lucito R,
Wigler MH

Biostatistics
  5 (4): 557-572; Oct 2004  
[Abstract]
[DOI] [Full Text]

Large-scale copy number polymorphism in the human genome
Sebat J,
Lakshmi B,
Troge JE,
Alexander J,
Young J,
Lundin P,
Maner S,
Massa H,
Walker M,
Chi M,
Navin NE,
Lucito R,
Healy J,
Hicks JB,
Ye K,
Reiner A,
Gilliam TC,
Trask B,
Patterson N,
Zetterberg A,
Wigler MH

Science
  305 (5683): 525-8; Jul 23 2004  
[Abstract]
[DOI] [Full Text]

Distribution of short paired duplications in mammalian genomes
Thomas EE,
Srebro N,
Sebat J,
Navin N,
Healy J,
Mishra B,
Wigler MH

Proc Natl Acad Sci U S A
  101 (28): 10349-54; Jul 13 2004  
[Abstract]
[DOI] [Full Text]

Annotating large genomes with exact word matches
Healy J,
Thomas EE,
Schwartz JT,
Wigler MH

Genome Research
  13 (10): 2306-2315; Oct 2003  
[Abstract]
[Full Text]

Representational oligonucleotide microarray analysis: A high-resolution method to detect genome copy number variation
Lucito R,
Healy J,
Alexander J,
Reiner A,
Esposito D,
Chi MY,
Rodgers L,
Brady A,
Sebat J,
Troge JE,
West JA,
Rostan S,
Nguyen KC,
Powers S,
Ye KQ,
Olshen A,
Venkatraman E,
Norton L,
Wigler MH

Genome Research
  13 (10): 2291-2305; Oct 2003  
[Abstract]
[DOI] [Full Text]

Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene
Mu D,
Chen LY,
Zhang XP,
See LH,
Koch CM,
Yen C,
Tong JJ,
Spiegel L,
Nguyen KC,
Servoss A,
Peng Y,
Pei L,
Marks JR,
Lowe S,
Hoey T,
Jan LY,
McCombie WR,
Wigler MH,
Powers S

Cancer Cell
  3 (3): 297-302; Mar 2003  
[Abstract]
[Full Text]

Preparation of slides and hybridization
Lucito R,
Wigler MH
In:
DNA microarrays : a molecular cloning manual
(eds. Bowtell, D. Sambrook, J.) Cold Spring Harbor, NY: Cold Spring Harbor L; 2003. : 394-399  


Preparation of target DNA
Lucito R,
Wigler MH
In:
DNA microarrays : a molecular cloning manual
(eds. Bowtell, D. Sambrook, J.) Cold Spring Harbor, NY: Cold Spring Harbor L; 2003. : 386-393  


DBC2, a candidate for a tumor suppressor gene involved in breast cancer
Hamaguchi M,
Meth JL,
von Klitzing C,
Wei W,
Esposito D,
Rodgers L,
Walsh T,
Welcsh P,
King MC,
Wigler MH

Proceedings of the National Academy of Sciences of the United States of America
  99 (21): 13647-13652; Oct 2002  
[Full Text]

Genetics - Wild by nature
Wigler MH,
Mishra B

Science
  296 (5572): 1407-1408; May 2002  
[Full Text]

Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor
Stolarov J,
Chang K,
Reiner A,
Rodgers L,
Hannon GJ,
Wigler MH,
Mittal V

Proceedings of the National Academy of Sciences of the United States of America
  98 (23): 13043-13048; Nov 2001  
[Abstract]
[DOI] [Full Text]

The Ras-Byr2RBD complex: Structural basis for Ras effector recognition in yeast
Scheffzek K,
Grunewald P,
Wohlgemuth S,
Kabsch W,
Tu H,
Wigler MH,
Wittinghofer A,
Herrmann C

Structure
  9 (11): 1043-1050; Nov 2001  
[Abstract]
[Full Text]

PTEN controls tumor-induced angiogenesis
Wen SH,
Stolarov J,
Myers MP,
Su JD,
Wigler MH,
Tonks NK,
Durden DL

Proceedings of the National Academy of Sciences of the United States of America
  98 (8): 4622-4627; Apr 2001  
[Abstract]
[Full Text]

Placing Probes along the Genome Using Pairwise Distance Data
Casey W,
Mishra B,
Wigler MH
In:
Algorithms in Bioinformatics: First International Workshop, WABI 2001, Aarhus, Denmark, August 28-31, 2001, Proceedings
(eds. ) Berlin / Heidelberg: Springer-Verlag; 2001. 2149: 52-68  
[Full Text]

Detecting gene copy number fluctuations in tumor cells by microarray analysis of genomic representations
Lucito R,
West J,
Reiner A,
Alexander J,
Esposito D,
Mishra B,
Powers S,
Norton L,
Wigler MH

Genome Research
  10 (11): 1726-1736; Nov 2000  
[Abstract]
[Full Text]

Molecular forceps from combinatorial libraries prevent the farnesylation of Ras by binding to its carboxyl terminus
Dong DL,
Liu R,
Sherlock R,
Wigler MH,
Nestler HP

Chem Biol
  6 (3): 133-41; Mar 1999  
[Abstract]
[DOI] [Full Text]

Genetic evidence for Pak1 autoinhibition and its release by Cdc42
Tu H,
Wigler MH

Mol Cell Biol
  19 (1): 602-11; Jan 1999  
[Abstract]
[Full Text] [PDF]

The lipid phosphatase activity of PTEN is critical for its tumor supressor function
Myers MP,
Pass I,
Batty IH,
Van der Kaay J,
Stolarov JP,
Hemmings BA,
Wigler MH,
Downes CP,
Tonks NK

Proc Natl Acad Sci U S A
  95 (23): 13513-8; Nov 10 1998  
[Abstract]
[Full Text]

Signaling pathways in Ras-mediated tumorigenicity and metastasis
Webb CP,
Van Aelst L,
Wigler MH,
Woude GF

Proc Natl Acad Sci U S A
  95 (15): 8773-8; Jul 21 1998  
[Abstract]
[DOI] [Full Text]

Genetic analysis using genomic representations
Lucito R,
Nakimura M,
West JA,
Han Y,
Chin K,
Jensen KR,
McCombie RW,
Gray JW,
Wigler MH

Proc Natl Acad Sci U S A
  95 (8): 4487-92; Apr 14 1998  
[Abstract]
[Full Text]

Rapid isolation of cDNA by hybridization
Hamaguchi M,
OConnor EA,
Chen T,
Parnell L,
McCombie RW,
Wigler MH

Proc Natl Acad Sci U S A
  95 (7): 3764-9; Mar 31 1998  
[Abstract]
[Full Text]

Multiple regulatory domains on the Byr2 protein kinase
Tu H,
Barr M,
Dong DL,
Wigler MH

Mol Cell Biol
  17 (10): 5876-87; Oct 1997  
[Abstract]
[Full Text]

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
Myers MP,
Stolarov JP,
Eng C,
Li J,
Wang SI,
Wigler MH,
Parsons R,
Tonks NK

Proc Natl Acad Sci U S A
  94 (17): 9052-7; Aug 19 1997  
[Abstract]
[Full Text]

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
Li J,
Yen C,
Liaw D,
Podsypanina K,
Bose S,
Wang SI,
Puc J,
Miliaresis C,
Rodgers L,
McCombie R,
Bigner SH,
Giovanella BC,
Ittmann M,
Tycko B,
Hibshoosh H,
Wigler MH,
Parsons R

Science
  275 (5308): 1943-7; Mar 28 1997  
[Abstract]
[DOI] [Full Text]

Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe
Barr MM,
Tu H,
Van Aelst L,
Wigler MH

Mol Cell Biol
  16 (10): 5597-603; Oct 1996  
[Abstract]
[Full Text]

A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation
White MA,
Vale T,
Camonis JH,
Schaefer E,
Wigler MH

J Biol Chem
  271 (28): 16439-42; Jul 12 1996  
[Abstract]
[Full Text]

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation
Khosravi-Far R,
White MA,
Westwick JK,
Solski PA,
Chrzanowska-Wodnicka M,
Van Aelst L,
Wigler MH,
Der CJ

Mol Cell Biol
  16 (7): 3923-33; Jul 1996  
[Abstract]
[Full Text]

Evaluation of the FHIT gene in colorectal cancers
Thiagalingam S,
Lisitsyn NA,
Hamaguchi M,
Wigler MH,
Willson JK,
Markowitz SD,
Leach FS,
Kinzler KW,
Vogelstein B

Cancer Res
  56 (13): 2936-9; Jul 1 1996  
[Abstract]
[Full Text]

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS
Joneson T,
White MA,
Wigler MH,
BarSagi D

Science
  271 (5250): 810-812; Feb 1996  
[Abstract]
[Full Text]

New polymorphic markers in the vicinity of the pearl locus on mouse chromosome 13
Xu HP,
Yanak BL,
Wigler MH,
Gorin MB

Mamm Genome
  7 (1): 16-9; Jan 1996  
[Abstract]
[DOI] [Full Text]

Cooperative interaction of S. pombe proteins required for mating and morphogenesis
Chang EC,
Barr M,
Wang Y,
Jung V,
Xu HP,
Wigler MH

Cell
  79 (1): 131-41; Oct 7 1994  
[Abstract]
[DOI] [Full Text]

Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module
Marcus S,
Polverino A,
Barr M,
Wigler MH

Proc Natl Acad Sci U S A
  91 (16): 7762-6; Aug 2 1994  
[Abstract]
[DOI] [Full Text]

Two types of RAS mutants that dominantly interfere with activators of RAS
Jung V,
Wei W,
Ballester R,
Camonis J,
Mi S,
Van Aelst L,
Wigler MH,
Broek D

Mol Cell Biol
  14 (6): 3707-18; Jun 1994  
[Abstract]
[DOI] [Full Text]

Conservation of Ste20-Related Protein-Kinases in Eukaryotes
Marcus S,
Polverino A,
Robbins D,
Cobb M,
Wigler MH

Faseb Journal
  8 (7): A1431-A1431; Apr 1994  


Ras partners
Van Aelst L,
White M,
Wigler MH

Cold Spring Harbor Symposia on Quantitative Biology LIX: Molecular Genetics of Cancer
  59 181-186; 1994  


Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe
Xu HP,
White M,
Marcus S,
Wigler MH

Mol Cell Biol
  14 (1): 50-8; Jan 1994  
[Abstract]
[DOI] [Full Text]

Detection of genetic loss in tumors by representational difference analysis
Lisitsyn NA,
Leach FS,
Vogelstein B,
Wigler MH

Cold Spring Harbor Symposia on Quantitative Biology LIX: Molecular Genetics of Cancer
  59 585-7; 1994  
[DOI] [Full Text]

Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis
Lisitsyn NA,
Segre JA,
Kusumi K,
Lisitsyn NM,
Nadeau JH,
Frankel WN,
Wigler MH,
Lander ES

Nat Genet
  6 (1): 57-63; Jan 1994  
[Abstract]
[DOI] [Full Text]

Complex synthetic chemical libraries indexed with molecular tags
Ohlmeyer MH,
Swanson RN,
Dillard LW,
Reader JC,
Asouline G,
Kobayashi R,
Wigler MH,
Still WC

Proceedings of the National Academy of Sciences of the United States of America
  90 (23): 10922-10926; Dec 1993  
[Abstract]
[Full Text]

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs
Bolger G,
Michaeli T,
Martins T,
St John T,
Steiner B,
Rodgers L,
Riggs M,
Wigler MH,
Ferguson K

Mol Cell Biol
  13 (10): 6558-71; Oct 1993  
[Abstract]
[Full Text]

Complex formation between RAS and RAF and other protein kinases
Van Aelst L,
Barr M,
Marcus S,
Polverino A,
Wigler MH

Proc Natl Acad Sci U S A
  90 (13): 6213-7; Jul 1 1993  
[Abstract]
[DOI] [Full Text]

Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase- deficient Saccharomyces cerevisiae
Michaeli T,
Bloom TJ,
Martins T,
Loughney K,
Ferguson K,
Riggs M,
Rodgers L,
Beavo JA,
Wigler MH

Journal of Biological Chemistry
  268 (17): 12925-12932; Jun 1993  
[Abstract]
[Full Text]

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
Chardin P,
Camonis JH,
Gale NW,
van Aelst L,
Schlessinger J,
Wigler MH,
Bar-Sagi D

Science
  260 (5112): 1338-1343; May 28 1993  
[Abstract]
[DOI] [Full Text]

Evolution of Ras Signal Transduction Pathways
Wigler MH,
Xu HP,
Vanaelst L,
Jung V,
Marcus S,
Polverino T,
Oneill K,
Chang E,
Camonis J,
Nicolette C,
White M,
Ballester R

Faseb Journal
  7 (7): A1124-A1124; Apr 1993  
[Full Text]

Analysis of the neurofibromatosis type-1 (NF1) GAP-related domain by site-directed mutagenesis
Gutmann DH,
Boguski M,
Marchuk D,
Wigler MH,
Collins FS,
Ballester R

Oncogene
  8 (3): 761-769; Mar 1993  
[Abstract]
[Full Text]

Cloning the differences between two complex genomes
Lisitsyn N,

Science
  259 (5097): 946-51; Feb 12 1993  
[Abstract]
[DOI] [Full Text]

Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms
Neiman AM,
Stevenson BJ,
Xu HP,
Sprague GF,
Herskowitz I,
Wigler MH,
Marcus S

Molecular Biology of the Cell
  4 (1): 107-120; Jan 1993  
[Abstract]
[Full Text]

RAS function and protein kinase cascades
Marcus S,
Wigler MH,
Xu HP,
Ballester R,
Kawamukai M,
Polverino A

Ciba Found Symp
  176 (0): 53-61; discussion 61; 1993  
[Abstract]


A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity
Andersen LB,
Ballester R,
Marchuk DA,
Chang E,
Gutmann DH,
Saulino AM,
Camonis J,
Wigler MH,
Collins FS

Molecular and Cellular Biology
  13 (1): 487-495; Jan 1993  
[Abstract]
[Full Text]

Oncogenic Ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes
Shibuya EK,
Polverino AJ,
Chang E,
Wigler MH,
Ruderman JV

Proceedings of the National Academy of Sciences of the United States of America
  89 (20): 9831-9835; Oct 1992  
[Abstract]
[Full Text]

A gene encoding a protein with seven zinc finger domains acts on the sexual differentiation pathways of Schizosaccharomyces pombe
Xu HP,
Rajavashisth T,
Grewal N,
Jung V,
Riggs M,
Rodgers L,
Wigler MH

Mol Biol Cell
  3 (7): 721-34; Jul 1992  
[Abstract]
[Full Text]

Snc1, a Yeast Homolog of the Synaptic Vesicle-Associated Membrane-Protein Synaptobrevin Gene Family - Genetic Interactions with the Ras and Cap Genes
Gerst JE,
Rodgers L,
Riggs M,
Wigler MH

Proceedings of the National Academy of Sciences of the United States of America
  89 (10): 4338-4342; May 1992  
[Abstract]
[Full Text]

Genetic and Biochemical-Analysis of the Adenylyl Cyclase-Associated Protein, Cap, in Schizosaccharomyces-Pombe
Kawamukai M,
Gerst J,
Field J,
Riggs M,
Rodgers L,
Wigler MH,
Young D

Molecular Biology of the Cell
  3 (2): 167-180; Feb 1992  
[Abstract]
[Full Text]

Alternative Splicing in the Proposed Catalytic Domain of the Type-1 Neurofibromatosis Gene
Andersen L,
Ballester R,
Marchuk D,
Saulino A,
Wigler MH,
Collins F

American Journal of Human Genetics
  49 (4): 21-21; Oct 1991  
[Full Text]

Evidence for a functional link between profilin and CAP in the yeast S. cerevisiae
Vojtek A,
Haarer B,
Field J,
Gerst J,
Pollard TD,
Brown S,
Wigler MH

Cell
  66 (3): 497-505; Aug 9 1991  
[Abstract]
[DOI] [Full Text]

byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype
Wang Y,
Xu HP,
Riggs M,
Rodgers L,
Wigler MH

Molecular Cellular Biology
  11 (7): 3554-63; Jul 1991  
[Abstract]
[Full Text] [PDF]

The Ras Oncoprotein and M-Phase Activity
Daar I,
Nebreda AR,
Yew N,
Sass P,
Paules R,
Santos E,
Wigler MH,
Vandewoude GF

Science
  253 (5015): 74-76; Jul 1991  
[Abstract]
[DOI] [Full Text]

The adenylyl cyclase-encoding gene from Saccharomyces kluyveri
Young D,
ONeill K,
Broek D,
Wigler MH

Gene
  102 (1): 129-32; Jun 15 1991  
[Abstract]
[DOI] [Full Text]

Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae
Colicelli J,
Nicolette C,
Birchmeier C,
Rodgers L,
Riggs M,
Wigler MH

Proc Natl Acad Sci U S A
  88 (7): 2913-7; Apr 1 1991  
[Abstract]
[DOI] [Full Text] [PDF]

CAP is a bifunctional component of the Saccharomyces cerevisiae adenylyl cyclase complex
Gerst JE,
Ferguson K,
Vojtek A,
Wigler MH,
Field J

Molecular Cellular Biology
  11 (3): 1248-57; Mar 1991  
[Abstract]
[Full Text] [PDF]

Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe
Kawamukai M,
Ferguson K,
Wigler MH,
Young D

Cell Regulation
  2 (2): 155-64; Feb 1991  
[Abstract]
[Full Text] [PDF]

The Ways of Ras
Wigler MH,
Ballester R,
Chang E,
Colicelli J,
Field J,
Gerst J,
Kawamukai M,
Michaeli T,
Nicolette C,
et al.

Proceedings American Association for Cancer Research Annual Meeting
  (0): 435; 1991  


The Ras Signalling Pathway in Yeast
Vojtek A,
Field J,
Gerst J,
Wigler MH

Journal of Cellular Biochemistry - Supplement.(15 PART B)
  (0): 84; 1991  


The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins
Ballester R,
Marchuk D,
Boguski M,
Saulino A,
Letcher R,
Wigler MH,
Collins F

Cell
  63 (4): 851-9; Nov 16 1990  
[Abstract]
[DOI] [Full Text]

Biological-Activity of the Mammalian Rap Genes in Yeast
Xu HP,
Wang Y,
Riggs M,
Rodgers L,
Wigler MH

Cell Regulation
  1 (10): 763-769; Sep 1990  
[Full Text] [PDF]

Oncoproteins. GAPs in understanding Ras
Wigler MH

Nature
  346 (6286): 696-7; Aug 23 1990   NLM
[DOI] [Full Text]

Oncoproteins - Gaps in Understanding Ras
Wigler MH

Nature
  346 (6286): 696-697; Aug 1990  
[DOI] [Full Text]

Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase
Colicelli J,
Field J,
Ballester R,
Chester N,
Young D,
Wigler MH

Molecular Cellular Biology
  10 (6): 2539-43; Jun 1990  
[Abstract]
[Full Text] [PDF]

A method for difference cloning: gene amplification following subtractive hybridization
Wieland I,
Bolger G,
Asouline G,
Wigler MH

Proc Natl Acad Sci U S A
  87 (7): 2720-4; Apr 1990  
[Abstract]
[DOI] [Full Text]

Cloning and characterization of CAP , the Saccharomyces cerevisiae gene encoding the 70 kDa adenylyl cyclase associated protein.
Field J,
Vojtek A,
Ballester R,
Bolger G,
Colicelli J,
Ferguson K,
Gerst J,
Kataoka T,
Michaeli T,
Powers S,
Riggs M,
Rodgers L,
Wieland I,
Wheland B,
Wigler MH

Cell
  61 (2): 319-327; Apr 1990  
[DOI] [Full Text]

Mutations of the adenylyl cyclase gene that block RAS function in Saccharomyces cerevisiae
Field J,
Xu HP,
Michaeli T,
Ballester R,
Sass P,
Wigler MH,
Colicelli J

Science
  247 (4941): 464-7; Jan 26 1990  
[Abstract]
[DOI] [Full Text]

A gene from Schizosaccharomyces-Pombe with homology to Escherichia-Coli RNAse III blocks conjugation and sporulation when overexpressed in wild type cells
Xu HP,
Riggs M,
Rodgers L,
Wigler MH

Nucleic Acids Research
  18 (17): 5304; 1990  
[DOI] [Full Text]

Molecular and Phenotypic Analysis of Cap a Regulatory Element Involved in Mediating Both Ras Action and Amino Acid Balance
Gerst JE,
Field J,
Ferguson K,
Wigler MH

Yeast
  6 (0): S174; 1990  


Characterization of Ros1 Complementary DNA from a Human Glioblastoma Cell Line
Birchmeier C,
ONeill K,
Riggs M,
Wigler MH

Proceedings of the National Academy of Sciences of the United States of America
  87 (12): 4799-4803; 1990  
[Abstract]
[DOI] [Full Text] [PDF]

Isolation and Characterization of Genes That Regulate Ras Function in the Yeast Saccharomyces-Cerevisiae
Ballester R,
Wigler MH

Yeast
  6 (0): S212; 1990  


Genetic analysis of mammalian GAP expressed in yeast
Ballester R,
Michaeli T,
Ferguson K,
Xu HP,
McCormick F,
Wigler MH

Cell
  59 (4): 681-6; Nov 17 1989  
[Abstract]
[DOI] [Full Text]

The adenylyl cyclase gene from Schizosaccharomyces pombe
Young D,
Riggs M,
Field J,
Vojtek A,
Broek D,
Wigler MH

Proc Natl Acad Sci U S A
  86 (20): 7989-93; Oct 1989  
[Abstract]
[DOI] [Full Text] [PDF]

Mutants of H-ras that interfere with RAS effector function in Saccharomyces cerevisiae
Michaeli T,
Field J,
Ballester R,
ONeill K,
Wigler MH

Embo J
  8 (10): 3039-44; Oct 1989  
[Abstract]
[Full Text] [PDF]

Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase
Colicelli J,
Birchmeier C,
Michaeli T,
ONeill K,
Riggs M,
Wigler MH

Proc Natl Acad Sci U S A
  86 (10): 3599-603; May 1989  
[Abstract]
[DOI] [Full Text]

Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae
Powers S,
ONeill K,
Wigler MH

Molecular Cellular Biology
  9 (2): 390-5; Feb 1989  
[Abstract]
[Full Text] [PDF]

Characterization of the ros1-gene products expressed in human glioblastoma cell lines
Sharma S,
Birchmeier C,
Nikawa J,
ONeill K,
Rodgers L,
Wigler MH

Oncogene Res
  5 (2): 91-100; 1989  
[Abstract]
[Full Text]

Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain
Young D,
ONeill K,
Jessell T,
Wigler MH

Proc Natl Acad Sci U S A
  85 (14): 5339-42; Jul 1988  
[Abstract]
[DOI] [Full Text]

cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae
Cameron S,
Levin L,
Zoller M,
Wigler MH

Cell
  53 (4): 555-66; May 20 1988  
[Abstract]
[DOI] [Full Text]

SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits
Toda T,
Cameron S,
Sass P,
Wigler MH

Genes Dev
  2 (5): 517-27; May 1988  
[Abstract]
[Full Text]

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method
Field J,
Nikawa J,
Broek D,
MacDonald B,
Rodgers L,
Wilson IA,
Lerner RA,
Wigler MH

Molecular Cellular Biology
  8 (5): 2159-65; May 1988  
[Abstract]
[Full Text]

A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation
Levin LR,
Kuret J,
Johnson KE,
Powers S,
Cameron S,
Michaeli T,
Wigler MH,
Zoller MJ

Science
  240 (4848): 68-70; Apr 1 1988  
[Abstract]
[DOI] [Full Text]

Studies of RAS function in the yeast Saccharomyces cerevisiae
Wigler MH,
Field J,
Powers S,
Broek D,
Toda T,
Cameron S,
Nikawa J,
Michaeli T,
Colicelli J,
Ferguson K

Cold Spring Harbor Symposia on Quantitative Biology LIII: Molecular Biology of Signal Transduction
  53 Pt 649-55; 1988  
[Full Text]

Integration of Ras and Adenylate Cyclase Pathways in Yeast
Wigler MH,
Cameron S,
Powers S,
Field J,
Toda T,
Broek D,
Nikawa J,
Michaelis T,
Colicelli J,
et al.

Journal of Cell Biology
  107 (6): 4A; 1988  


Expression and rearrangement of the ROS1 gene in human glioblastoma cells
Birchmeier C,
Sharma S,
Wigler MH

Proc Natl Acad Sci U S A
  84 (24): 9270-4; Dec 1987  
[Abstract]
[DOI] [Full Text]

Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae [published erratum appears in Genes Dev 1987 Dec;1(10):1351]
Nikawa J,
Cameron S,
Toda T,
Ferguson KM,
Wigler MH

Genes Development
  1 (9): 931-937; Nov 1 1987  
[DOI] [Full Text]

Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae
Nikawa J,
Sass P,
Wigler MH

Molecular Cellular Biology
  7 (10): 3629-36; Oct 1987  
[Abstract]
[Full Text]

Human ROS1 and MAS1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements
Rabin M,
Birnbaum D,
Young D,
Birchmeier C,
Wigler MH,
Ruddle FH

Oncogene Res
  1 (2): 169-78; Jul 1987  
[Abstract]


Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae
Toda T,
Cameron S,
Sass P,
Zoller M,
Scott JD,
McMullen B,
Hurwitz M,
Krebs EG,
Wigler MH

Molecular Cellular Biology
  7 (4): 1371-1377; Apr 1987  
[Abstract]
[Full Text] [PDF]

The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway
Broek D,
Toda T,
Michaeli T,
Levin L,
Birchmeier C,
Zoller M,
Powers S,
Wigler MH

Cell
  48 (5): 789-800; Mar 1987  
[Abstract]
[DOI] [Full Text]

Three different genes in Saccharomyces cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase
Toda T,
Cameron S,
Sass P,
Zoller M,
Wigler MH

Cell
  50 (2): 277-288; 1987  
[Abstract]
[DOI] [Full Text]

Exploring the function of RAS oncogenes by studying the yeast Saccharomyces cerevisiae
Toda T,
Broek D,
Field J,
Michaeli T,
Cameron S,
Nikawa J,
Sass P,
Birchmeier C,
Powers S,
Wigler MH
In:
Oncogenes and cancer : proceedings of the 17th International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo, 1986
(ed. Aaronson, Stuart A.) Tokyo: Japan Scientific Soc; 1987. 17: 253-260  
[Abstract]
[Full Text]

Yeast Mating Pheromone a-Factor and Its Relationship to Ras Proteins
Michaelis S,
Anna SS,
Powers S,
Wigler MH,
Herskowitz I

Journal of Cellular Biochemistry
  (0): 261-261; 1987  
[Full Text]

Expression in Escherichia coli of BCY1, the regulatory subunit of cyclic AMP-dependent protein kinase from Saccharomyces cerevisiae.
Johnson KE,
Cameron S,
Toda T,
Wigler MH,
Zoller MJ

Journal of Biological Chemistry
  262 (18): 8636-8642; 1987  
[Abstract]
[Full Text] [PDF]

Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae
Field J,
Broek D,
Kataoka T,
Wigler MH

Molecular Cellular Biology
  7 (6): 2128-2133; 1987  
[Abstract]
[Full Text] [PDF]

Induction of Oocyte Maturation by Injection of Oncogenic H-Ras Protein in the Starfish
Herlands L,
Kishimoto T,
Birchmeier C,
Wigler MH,
Koide SS

Zoological Science
  3 (6): 1036-1036; Dec 1986  
[Full Text]

Characterization of two new human oncogenes
Birchmeier C,
Young D,
Wigler MH

Cold Spring Harbor Symposia on Quantitative Biology LI: Molecular Biology of Homo Sapiens
  51. 993; June 1986  


Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains