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54 Article(s) on File
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In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer
Rudalska R,
Dauch D,
Longerich T,
McJunkin K,
Wuestefeld T,
Kang TW,
Hohmeyer A,
Pesic M,
Leibold J,
von Thun A,
Schirmacher P,
Zuber J,
Weiss KH,
Powers S,
Malek NP,
Eilers M,
Sipos B,
Lowe SW,
Geffers R,
Laufer S,
Zender L

Nature Medicine
  20 (10): 1138-1146; Oct 2014   NLM
[Abstract]
[DOI] [Full Text]

Identification of Driver Genes in Hepatocellular Carcinoma by Exome Sequencing
Cleary SP,
Jeck WR,
Zhao XB,
Chen K,
Selitsky SR,
Savich GL,
Tan TX,
Wu MC,
Getz G,
Lawrence MS,
Parker JS,
Li JY,
Powers S,
Kim H,
Fischer S,
Guindi M,
Ghanekar A,
Chiang DY

Hepatology
  58 (5): 1693-1702; Nov 2013   NLM
[Abstract]
[DOI] [Full Text]

Identification of driver genes in hepatocellular carcinoma by exome sequencing
Cleary SP,
Jeck WR,
Zhao XB,
Selitsky SR,
Savich GL,
Tan TX,
Wu MC,
Getz G,
Lawrence MS,
Parker JS,
Li JY,
Powers S,
Kim H,
Fischer SE,
Guindi M,
Ghanekar A,
Chiang DY

Cancer Research
  73 (8): 4598; Apr 2013  
[Abstract]
[DOI] [Full Text]

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions
Xue W,
Kitzing T,
Roessler S,
Zuber J,
Krasnitz A,
Schultz N,
Revill K,
Weissmueller S,
Rappaport AR,
Simon J,
Zhang J,
Luo WJ,
Hicks J,
Zender L,
Wang XW,
Powers S,
Wigler M,
Lowe SW

Proceedings of the National Academy of Sciences of the United States of America
  109 (21): 8212-8217; May 2012  
[Abstract]
[DOI] [Full Text]

Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1)
Liu-Sullivan N,
Zhang J,
Bakleh A,
Marchica J,
Li J,
Siolas D,
Laquerre S,
Degenhardt YY,
Wooster R,
Chang K,
Hannon GJ,
Powers S

Oncotarget
  2 (12): 1254-64; Dec 2011   Nlm
[Abstract]
[DOI] [Full Text]

Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis
Storm P,
Aits S,
Puthia MK,
Urbano A,
Northen T,
Powers S,
Bowen B,
Chao Y,
Reindl W,
Lee DY,
Sullivan NL,
Zhang J,
Trulsson M,
Yang H,
Watson JD,
Svanborg C

Oncogene
  (0): Jun 6 2011  
[Abstract]
[DOI] [Full Text]

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening
Sawey ET,
Chanrion M,
Cai C,
Wu G,
Zhang J,
Zender L,
Zhao A,
Busuttil RW,
Yee H,
Stein LD,
French DM,
Finn RS,
Lowe SW,
Powers S

Cancer Cell
  19 (3): 347-358; Mar 8 2011   Elsevier PMC3061399
[Abstract]
[DOI]

Testing and Validating High Throughput Genomic Analysis of FFPE Samples: Systematic Gene Expression Differences between Matched Frozen and FFPE Samples Due to Rapid mRNA Degradation Signals
Cabal R,
Khanin R,
Viali A,
Socci N,
Lucito R,
Olshen A,
Zhang J,
Gerald W,
Powers S,
Ladanyi M

Modern Pathology
  24 (0): 1875; Feb 2011  
[Full Text]

Towards patient-based cancer therapeutics
Schreiber SL,
Shamji AF,
Clemons PA,
Hon C,
Koehler AN,
Munoz B,
Palmer M,
Stern AM,
Wagner BK,
Powers S,
Lowe SW,
Guo X,
Krasnitz A,
Sawey ET,
Sordella R,
Stein LD,
Trotman LC,
Califano A,
Dalla-Favera R,
Ferrando A,
Iavarone A,
Pasqualucci L,
Silva J,
Stockwell BR,
Hahn WC,
Chin L,
DePinho RA,
Boehm JS,
Gopal S,
Huang A,
Root DE,
Weir BA,
Gerhard DS,
Zenklusen JC,
Roth MG,
White MA,
Minna JD,
MacMillan JB,
Posner BA

Nature Biotechnology
  28 (9): 904-906; Sep 2010   PMCID: PMC2939009
[DOI] [Full Text] [PDF]

New views into the prostate cancer genome
Trotman LC,
Powers S

Cancer Cell
  18 (1): 1-2; Jul 13 2010  
[Abstract]
[DOI] [Full Text] [PDF]

Sensitivity of Cancer Cells to Plk1 Inhibitor GSK461364A Is Associated with Loss of p53 Function and Chromosome Instability
Degenhardt Y,
Greshock J,
Laquerre S,
Gilmartin AG,
Jing J,
Richter M,
Zhang X,
Bleam M,
Halsey W,
Hughes A,
Moy C,
Liu-Sullivan N,
Powers S,
Bachman K,
Jackson J,
Weber B,
Wooster R

Mol Cancer Ther
  (0): July 2010  
[Abstract]
[DOI] [Full Text] [PDF]

Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer
Oliver TG,
Mercer KL,
Sayles LC,
Burke JR,
Mendus D,
Lovejoy KS,
Cheng MH,
Subramanian A,
Mu D,
Powers S,
Crowley D,
Bronson RT,
Whittaker CA,
Bhutkar A,
Lippard SJ,
Golub T,
Thomale J,
Jacks T,
Sweet-Cordero EA

Genes Development
  24 (8): 837-852; Apr 2010   PMCID: PMC2854397
[Abstract]
[DOI] [Full Text] [PDF]

Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model
Bric A,
Miething C,
Bialucha CU,
Scuoppo C,
Zender L,
Krasnitz A,
Xuan Z,
Zuber J,
Wigler MH,
Hicks JB,
McCombie RW,
Hemann MT,
Hannon GJ,
Powers S,
Lowe SW

Cancer Cell
  16 (4): 324-35; Oct 6 2009   PMC2829755
[Abstract]
[DOI] [Full Text] [PDF]

Cyfip1 is a putative invasion suppressor in epithelial cancers
Silva JM,
Ezhkova E,
Silva J,
Heart S,
Castillo M,
Campos Y,
Castro V,
Bonilla F,
Cordon-Cardo C,
Muthuswamy SK,
Powers S,
Fuchs E,
Hannon GJ

Cell
  137 (6): 1047-61; Jun 12 2009   PMCID: PMC2754270
[Abstract]
[DOI] [Full Text] [PDF]

Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer
Hsu DS,
Acharya CR,
Balakumaran BS,
Riedel RF,
Kim MK,
Stevenson M,
Tuchman S,
Mukherjee S,
Barry W,
Dressman HK,
Nevins JR,
Powers S,
Mu D,
Potti A

Proc Natl Acad Sci U S A
  106 (13): 5312-5317; Mar 31 2009   PMCID: PMC2664027
[Abstract]
[DOI] [Full Text] [PDF]

A Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer
Starr TK,
Allaei R,
Silverstein KA,
Staggs RA,
Sarver AL,
Bergemann TL,
Gupta M,
OSullivan MG,
Matise I,
Dupuy AJ,
Collier LS,
Powers S,
Oberg AL,
Asmann YW,
Thibodeau SN,
Tessarollo L,
Copeland NG,
Jenkins NA,
Cormier RT,
Largaespada DA

Science
  323 (5922): 1747-1750; Mar 27 2009   PMCID: PMC2743396
[Abstract]
[DOI] [Full Text] [PDF]

A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma
Keng VW,
Villanueva A,
Chiang DY,
Dupuy AJ,
Ryan BJ,
Matise I,
Silverstein KA,
Sarver A,
Starr TK,
Akagi K,
Tessarollo L,
Collier LS,
Powers S,
Lowe SW,
Jenkins NA,
Copeland NG,
Llovet JM,
Largaespada DA

Nature Biotechnology
  27 (3): 264-274; Mar 2009   PMCID: PMC2712727
[Abstract]
[DOI] [Full Text] [PDF]

Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations
Sangha N,
Wu R,
Kuick R,
Powers S,
Mu D,
Fiander D,
Yuen K,
Katabuchi H,
Tashiro H,
Fearon ER,
Cho KR

Neoplasia
  10 (12): 1362-72; Dec 2008   PMCID: PMC2586687
[Abstract]
[Full Text] [PDF]

An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer
Zender L,
Xue W,
Zuber J,
Semighini CP,
Krasnitz A,
Ma B,
Zender P,
Kubicka S,
Luk JM,
Schirmacher P,
McCombie WR,
Wigler MH,
Hicks JB,
Hannon GJ,
Powers S,
Lowe SW

Cell
  135 (5): 852-864; Nov 28 2008   PMC2990916
[Abstract]
[DOI] [Full Text] [PDF]

Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model
Miao J,
Mu D,
Ergel B,
Singavarapu R,
Duan Z,
Powers S,
Oliva E,
Orsulic S

Int J Cancer
  123 (9): 2041-7; Nov 1 2008   PMCID: PMC2653430
[Abstract]
[DOI] [Full Text] [PDF]

DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma
Xue W,
Krasnitz A,
Lucito R,
Sordella R,
Van Aelst L,
Cordon-Cardo C,
Singer S,
Kuehnel F,
Wigler MH,
Powers S,
Zender L,
Lowe SW

Genes Dev
  22 (11): 1439-44; Jun 1 2008   PMCID: PMC2418580
[Abstract]
[DOI] [Full Text] [PDF]

Erythropoietin receptor transcription is neither elevated nor predictive of surface expression in human tumour cells
Sinclair AM,
Rogers N,
Busse L,
Archibeque I,
Brown W,
Kassner PD,
Watson JE,
Arnold GE,
Nguyen KC,
Powers S,
Elliott S

British Journal of Cancer
  98 (6): 1059-1067; Mar 2008   PMCID: PMC2275479
[Abstract]
[DOI] [Full Text] [PDF]

High-content analysis of cancer genome DNA alterations
Degenhardt YY,
Wooster R,
McCombie RW,
Lucito R,
Powers S

Current Opinion in Genetics Development
  18 (1): 68-72; Feb 2008   PMCID: PMC2729060
[Abstract]
[DOI] [Full Text] [PDF]

Genetic similarities between organogenesis and tumorigenesis of the lung
Powers S,
Mu D

Cell Cycle
  7 (2): 200 - 204 ; Jan 15 2008  
[Abstract]
[PDF]

Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer
Kendall JT,
Liu QA,
Bakleh A,
Krasnitz A,
Nguyen KC,
Lakshmi B,
Gerald W,
Powers S,
Mu D

Proc Natl Acad Sci U S A
  104 (42): 16663-16668; Oct 16 2007   PMCID: PMC2034240
[Abstract]
[DOI] [Full Text] [PDF]

Identification of alterations in DNA copy number in host stromal cells during tumor progression
Pelham RJ,
Rodgers L,
Hall IM,
Lucito R,
Nguyen KC,
Navin NE,
Hicks JB,
Mu D,
Powers S,
Wigler MH,
Botstein D

Proc Natl Acad Sci U S A
  103 (52): 19848-19853; Dec 2006  
[Abstract]
[DOI] [Full Text]

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
Zender L,
Spector MS,
Xue W,
Flemming P,
Cordon-Cardo C,
Silke J,
Fan ST,
Luk JM,
Wigler MH,
Hannon GJ,
Mu D,
Lucito R,
Powers S,
Lowe SW

Cell
  125 (7): 1253-67; Jun 30 2006  
[Abstract]
[DOI] [Full Text] [PDF]

Representational oligonucleotide microarray (ROMA) identifies cIAP1/cIAP2 as candidate oncogenes in mouse and human hepatocarcinogenesis-validation of cIAP1 as a therapeutic target in liver cancer in a new mouse model of hepatocellular carcinoma
Zender L,
Spector MS,
Xue W,
Flemming P,
Mu D,
Cordon-Cardo C,
Powers S,
Hannon GJ,
Lucito R,
Lowe SW

Hepatology
  42 (4): 244A-244A; Oct 2005  
[Full Text]

Generation and Analysis of Genetically Defined Liver Carcinomas Derived from Bipotential Liver Progenitors
Zender L,
Xue W,
Cordon-Cardo C,
Hannon GJ,
Lucito R,
Powers S,
Flemming P,
Spector MS,
Lowe SW

Cold Spring Harbor Symposia on Quantitative Biology VXX: Molecular approaches to controlling cancer
  70 251-261; 2005  
[Abstract]
[DOI] [Full Text] [PDF]

Wip1-deficient mice are resistant to common cancer genes
Harrison M,
Li J,
Degenhardt Y,
Hoey T,
Powers S

Trends in Molecular Medicine
  10 (8): 359-361; Aug 2004  
[Abstract]
[DOI] [Full Text] [PDF]

Representational oligonucleotide microarray analysis: A high-resolution method to detect genome copy number variation
Lucito R,
Healy J,
Alexander J,
Reiner A,
Esposito D,
Chi MY,
Rodgers L,
Brady A,
Sebat J,
Troge JE,
West JA,
Rostan S,
Nguyen KC,
Powers S,
Ye KQ,
Olshen A,
Venkatraman E,
Norton L,
Wigler MH

Genome Research
  13 (10): 2291-2305; Oct 2003  
[Abstract]
[DOI] [Full Text]

Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene
Mu D,
Chen LY,
Zhang XP,
See LH,
Koch CM,
Yen C,
Tong JJ,
Spiegel L,
Nguyen KC,
Servoss A,
Peng Y,
Pei L,
Marks JR,
Lowe S,
Hoey T,
Jan LY,
McCombie WR,
Wigler MH,
Powers S

Cancer Cell
  3 (3): 297-302; Mar 2003  
[Abstract]
[Full Text]

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23
Li J,
Yang Y,
Peng Y,
Austin RJ,
van Eyndhoven G,
Nguyen KC,
Gabriele T,
McCurrach ME,
Marks JR,
Hoey T,
Lowe SW,
Powers S

Nature Genetics
  31 (2): 133-134; Jun 2002  
[Full Text]

Detecting gene copy number fluctuations in tumor cells by microarray analysis of genomic representations
Lucito R,
West J,
Reiner A,
Alexander J,
Esposito D,
Mishra B,
Powers S,
Norton L,
Wigler MH

Genome Research
  10 (11): 1726-1736; Nov 2000  
[Abstract]
[Full Text]

Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein
Field J,
Vojtek A,
Ballester R,
Bolger G,
Colicelli J,
Ferguson K,
Gerst J,
Kataoka T,
Michaeli T,
Powers S,
et al.

Cell
  61 (2): 319-27; Apr 20 1990  
[Abstract]
[DOI] [Full Text]

Cloning and characterization of CAP , the Saccharomyces cerevisiae gene encoding the 70 kDa adenylyl cyclase associated protein.
Field J,
Vojtek A,
Ballester R,
Bolger G,
Colicelli J,
Ferguson K,
Gerst J,
Kataoka T,
Michaeli T,
Powers S,
Riggs M,
Rodgers L,
Wieland I,
Wheland B,
Wigler MH

Cell
  61 (2): 319-327; Apr 1990  
[DOI] [Full Text]

Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae
Powers S,
ONeill K,
Wigler MH

Molecular Cellular Biology
  9 (2): 390-5; Feb 1989  
[Abstract]
[Full Text] [PDF]

A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation
Levin LR,
Kuret J,
Johnson KE,
Powers S,
Cameron S,
Michaeli T,
Wigler MH,
Zoller MJ

Science
  240 (4848): 68-70; Apr 1 1988  
[Abstract]
[DOI] [Full Text]

Studies of RAS function in the yeast Saccharomyces cerevisiae
Wigler MH,
Field J,
Powers S,
Broek D,
Toda T,
Cameron S,
Nikawa J,
Michaeli T,
Colicelli J,
Ferguson K

Cold Spring Harbor Symposia on Quantitative Biology LIII: Molecular Biology of Signal Transduction
  53 Pt 649-55; 1988  
[Full Text]

Integration of Ras and Adenylate Cyclase Pathways in Yeast
Wigler MH,
Cameron S,
Powers S,
Field J,
Toda T,
Broek D,
Nikawa J,
Michaelis T,
Colicelli J,
et al.

Journal of Cell Biology
  107 (6): 4A; 1988  


The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway
Broek D,
Toda T,
Michaeli T,
Levin L,
Birchmeier C,
Zoller M,
Powers S,
Wigler MH

Cell
  48 (5): 789-800; Mar 1987  
[Abstract]
[DOI] [Full Text]

Exploring the function of RAS oncogenes by studying the yeast Saccharomyces cerevisiae
Toda T,
Broek D,
Field J,
Michaeli T,
Cameron S,
Nikawa J,
Sass P,
Birchmeier C,
Powers S,
Wigler MH
In:
Oncogenes and cancer : proceedings of the 17th International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo, 1986
(ed. Aaronson, Stuart A.) Tokyo: Japan Scientific Soc; 1987. 17: 253-260  
[Abstract]
[Full Text]

Yeast Mating Pheromone a-Factor and Its Relationship to Ras Proteins
Michaelis S,
Anna SS,
Powers S,
Wigler MH,
Herskowitz I

Journal of Cellular Biochemistry
  (0): 261-261; 1987  
[Full Text]

RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor
Powers S,
Michaelis S,
Broek D,
Ann-A SS,
Field J,
Herskowitz I,
Wigler MH

Cell
  47 (3): 413-422; 1986  
[Abstract]
[DOI] [Full Text]

Ras Proteins Function Exclusively to Modulate Adenylate-Cyclase Activity in the Yeast Saccharomyces
Broach J,
Toda T,
Kataoka T,
Powers S,
Broek D,
Wigler MH

DNA-a Journal of Molecular Cellular Biology
  4 (1): 64-64; 1985  
[Full Text]

Conservation and divergence of RAS protein function during evolution
Birchmeier C,
Broek D,
Toda T,
Powers S,
Kataoka T,
Wigler MH

Cold Spring Harbor Symposia on Quantitative Biology L: Molecular Biology of Development
  721; 1985  


Functional homology of mammalian and yeast RAS genes
Kataoka T,
Powers S,
Cameron S,
Fasano O,
Goldfarb M,
Broach J,
Wigler MH

Cell
  40 (1): 19-26; 1985  
[Abstract]
[DOI] [Full Text]

Function of Yeast Ras Genes
Wigler MH,
Powers S,
Kataoka T,
Toda T,
Fasano O,
Matsumoto K,
Uno I,
Ishikawa T,
Broach J
In:
Genetics, cell differentiation, and cancer
(ed. Marks, P. A.) Orlando: Academic Press; 1985. 7: 153-164  


In yeast, RAS proteins are controlling elements of adenylate cyclase
Toda T,
Uno I,
Ishikawa T,
Powers S,
Kataoka T,
Broek D,
Cameron S,
Broach J,
Matsumoto K,
Wigler MH

Cell
  40 (1): 27-36; 1985  
[Abstract]
[DOI] [Full Text]

Control of Yeast Adenyl-Cyclase by Ras Proteins
Powers S,
Kataoka T,
Toda T,
Fasano O,
Wigler MH

Federation Proceedings
  44 (3): R8-R8; 1985  
[Full Text]

Control of the Cell-Cycle in Yeast
Powers S

Nature
  318 (6041): 20-20; 1985  
[Full Text]

Genetic analysis of yeast RAS1 and RAS2 genes
Kataoka T,
Powers S,
McGill C,
Fasano O,
Strathern J,
Broach J,
Wigler MH

Cell
  37 (2): 437-445; Jun 1984  
[DOI] [Full Text]

Genes in Saccharomyces cerevisiae encoding proteins with domains homologous to the mammalian ras proteins
Powers S,
Kataoka T,
Fasano O,
Goldfarb M,
Strathern J,
Broach J,
Wigler MH

Cell
  36 (3): 607-612; Mar 1984  
[Abstract]
[DOI] [Full Text]

Structure and Activation of Ras Genes
Wigler MH,
Fasano O,
Taparowsky E,
Powers S,
Kataoka T,
Birnbaum D,
Shimizu K,
Goldfarb M
In:
Oncogenes and viral genes
(ed. Vande Woude, G. F.) Cold Spring Harbor, NY: Cold Spring Harbor L; 1984. 2: 419-424  



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