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22 Article(s) on File
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Structural Determinants and Mechanism of Action of a GluN2C-selective NMDA Receptor Positive Allosteric Modulator
Khatri A,
Burger PB,
Swanger SA,
Hansen KB,
Zimmerman S,
Karakas E,
Liotta DC,
Furukawa H,
Snyder JP,
Traynelis SF

Mol Pharmacol
  86 (5): 548-560; Sep 9 2014   Nlm
[Abstract]
[DOI] [Full Text]

Crystal structure of a heterotetrameric NMDA receptor ion channel
Karakas E,
Furukawa H

Science
  344 (6187): 992-7; May 30 2014   NLM
[Abstract]
[DOI] [Full Text]

Structural Insights into Competitive Antagonism in NMDA Receptors
Jespersen A,
Tajima N,
Fernandez-Cuervo G,
Garnier-Amblard EC,
Furukawa H

Neuron
  81 (2): 366-78; Jan 22 2014   Nlm
[Abstract]
[DOI] [Full Text]

Structural determinants of agonist efficacy at the glutamate binding site of n-methyl-d-Aspartate receptorss
Hansen KB,
Tajima N,
Risgaard R,
Perszyk RE,
Jorgensen L,
Vance KM,
Ogden KK,
Clausen RP,
Furukawa H,
Traynelis SF

Molecular Pharmacology
  84 (1): 114-127; Jul 2013  
[DOI] [Full Text]

A eukaryotic specific transmembrane segment is required for tetramerization in AMPA receptors
Salussolia CL,
Gan Q,
Kazi R,
Singh P,
Allopenna J,
Furukawa H,
Wollmuth LP

Journal of Neuroscience
  33 (23): 9840-9845; Jun 5 2013   NLM
[Abstract]
[DOI] [Full Text]

Mapping the Binding of GluN2B-Selective N-Methyl-D-aspartate Receptor Negative Allosteric Modulators
Burger PB,
Yuan HJ,
Karakas E,
Geballe M,
Furukawa H,
Liotta DC,
Snyder JP,
Traynelis SF

Molecular Pharmacology
  82 (2): 344-359; Aug 2012  
[Abstract]
[DOI] [Full Text]

Structure and function of glutamate receptor amino terminal domains
Furukawa H

Journal of Physiology
  590 (1): 63-72; Feb 14 2012  
[Abstract]
[DOI] [Full Text]

Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors
Karakas E,
Simorowski N,
Furukawa H

Nature
  475 (7355): 249- U170; Jul 14 2011   PMC3171209
[Abstract]
[DOI]

Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors
Vance KM,
Simorowski N,
Traynelis SF,
Furukawa H

Nature Communications
  2 (0): Apr 2011  
[Abstract]
[DOI]

Control of Assembly and Function of Glutamate Receptors by the Amino-Terminal Domain
Hansen KB,
Furukawa H,
Traynelis SF

Molecular Pharmacology
  78 (4): 535-549; Oct 2010   PMCID: PMC2981397
[Abstract]
[DOI] [Full Text] [PDF]

Structural Insights into Allosteric Modulation of NMDA Receptors Through the Amino-Terminal Domain
Karakas E,
Simorowski N,
Furukawa H

Biophysical Journal
  98 (3): 609a-609a; Jan 2010  
[Abstract]
[DOI] [Full Text] [PDF]

Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit
Karakas E,
Simorowski N,
Furukawa H

Embo J
  28 (24): 3910-3920; Nov 12 2009   PMC2797058
[Abstract]
[DOI] [Full Text] [PDF]

Crystal structure and association behaviour of the GluR2 amino-terminal domain
Jin R,
Singh SK,
Gu S,
Furukawa H,
Sobolevsky AI,
Zhou J,
Jin Y,
Gouaux E

Embo J
  28 (12): 1812-23; Jun 17 2009   PMCID: PMC2699365 [A
[Abstract]
[DOI] [Full Text] [PDF]

Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH
Jasti J,
Furukawa H,
Gonzales EB,
Gouaux E

Nature
  449 (7160): 316-23; Sep 20 2007  
[Abstract]
[DOI] [Full Text] [PDF]

An optimized purification and reconstitution method for the MscS channel: strategies for spectroscopical analysis
Vasquez V,
Cortes DM,
Furukawa H,
Perozo E

Biochemistry
  46 (23): 6766-73; Jun 12 2007  
[Abstract]
[DOI] [Full Text]

Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif
Takahashi H,
Shin Y,
Cho SJ,
Zago WM,
Nakamura T,
Gu Z,
Ma Y,
Furukawa H,
Liddington R,
Zhang D,
Tong G,
Chen HS,
Lipton SA

Neuron
  53 (1): 53-64; Jan 4 2007   PMCID: PMC1855274
[Abstract]
[DOI] [Full Text] [PDF]

Subunit arrangement and function in NMDA receptors
Furukawa H,
Singh SK,
Mancusso R,
Gouaux E

Nature
  438 (7065): 185-192; Nov 10 2005  
[Abstract]
[DOI] [Full Text] [PDF]

Mechanism of partial agonist action at the NR1 subunit of NMDA receptors
Inanobe A,
Furukawa H,
Gouaux E

Neuron
  47 (1): 71-84; Jul 7 2005  
[Abstract]
[DOI] [Full Text] [PDF]

Determination of steric structure of muscarinic ligands bound to muscarinic receptors: approaches by TRNOE (transferred nuclear Overhauser effect).
Furukawa H,
Hamada T,
Ishiguro M,
Hirota H,
Haga T
In:
G protein-coupled receptors: structure, function, and ligand screening
(ed. ) : CRC Press; 2005. : 261-281   EPR Migration 03/201


Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Furukawa H,
Gouaux E

Embo J
  22 (12): 2873-85; Jun 16 2003   PMCID: PMC162155
[Abstract]
[Full Text] [PDF]

Conformation of ligands bound to the muscarinic acetylcholine receptor
Furukawa H,
Hamada T,
Hayashi MK,
Haga T,
Muto Y,
Hirota H,
Yokoyama S,
Nagasawa K,
Ishiguro M

Mol Pharmacol
  62 (4): 778-87; Oct 2002  
[Abstract]
[DOI] [Full Text] [PDF]

Expression of functional M2 muscarinic acetylcholine receptor in Escherichia coli
Furukawa H,
Haga T

J Biochem
  127 (1): 151-61; Jan 2000  
[Abstract]
[Full Text] [PDF]


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