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17 Article(s) on File
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Proffered Paper: Next Generation RNAi Mouse Models for Drug Discovery and Toxicology Assessment
Premsrirut P,
Fellmann C,
Hannon GJ,
Lowe SW,
Zuber J,
Elledge S

European Journal of Cancer
  48 (0): S14-S14; Jul 2012  
[Full Text]

Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy
Tan X,
Lu ZJ,
Gao G,
Xu QK,
Hu L,
Fellmann C,
Li MZ,
Qu HJ,
Lowe SW,
Hannon GJ,
Elledge SJ

Proceedings of the National Academy of Sciences of the United States of America
  109 (3): 869-874; Jan 2012  
[Abstract]
[DOI] [Full Text]

Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay
Fellmann C,
Zuber J,
McJunkin K,
Chang K,
Malone CD,
Dickins R,
Xu Q,
Hengartner M,
Elledge SJ,
Hannon GJ,
Lowe SW

Molecular Cell
  41 (6): 733-746; Mar 18 2011   Array
[Abstract]
[DOI]

Design of 240,000 orthogonal 25mer DNA barcode probes
Xu Q,
Schlabach MR,
Hannon GJ,
Elledge SJ

Proc Natl Acad Sci U S A
  106 (7): 2289-94; Feb 17 2009   PMCID: PMC2631075
[Abstract]
[DOI] [Full Text] [PDF]

Profiling essential genes in human mammary cells by multiplex RNAi screening
Silva JM,
Marran K,
Parker JS,
Silva J,
Golding M,
Schlabach MR,
Elledge SJ,
Hannon GJ,
Chang K

Science
  319 (5863): 617-20; Feb 1 2008   PMC2981870
[Abstract]
[DOI] [Full Text] [PDF]

Cancer proliferation gene discovery through functional Genomics
Schlabach MR,
Luo J,
Solimini NL,
Hu G,
Xu QK,
Li MZ,
Zhao ZM,
Smogorzewska A,
Sowa ME,
Ang XL,
Westbrook TF,
Liang AC,
Chang K,
Hackett JA,
Harper JW,
Hannon GJ,
Elledge SJ

Science
  319 (5863): 620-624; Feb 2008   PMC2981870
[Abstract]
[DOI] [Full Text] [PDF]

A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling
Draviam VM,
Stegmeier F,
Nalepa G,
Sowa ME,
Chen J,
Liang A,
Hannon GJ,
Sorger PK,
Harper JW,
Elledge SJ

Nature Cell Biology
  9 (5): 556-564; May 2007  
[Abstract]
[DOI] [Full Text] [PDF]

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities
Stegmeier F,
Rape M,
Draviam VM,
Nalepa G,
Sowa ME,
Ang XL,
McDonald ER,
Li MZ,
Hannon GJ,
Sorger PK,
Kirschner MW,
Harper JW,
Elledge SJ

Nature
  446 (7138): 876-881; Apr 2007  
[Abstract]
[DOI] [Full Text]

Lessons from Nature: microRNA-based shRNA libraries
Chang K,
Elledge SJ,
Hannon GJ

Nat Methods
  3 (9): 707-14; Sep 2006  
[Abstract]
[DOI] [Full Text] [PDF]

Second-generation shRNA libraries covering the mouse and human genomes
Silva JM,
Li MZ,
Chang K,
Ge W,
Golding MC,
Rickles RJ,
Siolas D,
Hu G,
Paddison PJ,
Schlabach MR,
Sheth N,
Bradshaw J,
Burchard J,
Kulkarni A,
Cavet G,
Sachidanandam R,
McCombie WR,
Cleary MA,
Elledge SJ,
Hannon GJ

Nat Genet
  37 (11): 1281-8; Nov 2005  
[Abstract]
[DOI] [Full Text]

An open letter to cancer researchers
Elledge SJ,
Hannon GJ

Science
  310 (5747): 439-41; Oct 2005  
[DOI] [Full Text] [PDF]

A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells
Stegmeier F,
Hu G,
Rickles RJ,
Hannon GJ,
Elledge SJ

Proceedings of the National Academy of Sciences of the United States of America
  102 (37): 13212-13217; Sep 2005  
[Abstract]
[Full Text]

A genetic screen for candidate tumor suppressors identifies REST
Westbrook TF,
Martin ES,
Schlabach MR,
Leng YM,
Liang AC,
Feng B,
Zhao JJ,
Roberts TM,
Mandel G,
Hannon GJ,
DePinho RA,
Chin L,
Elledge SJ

Cell
  121 (6): 837-848; Jun 2005  
[Abstract]
[DOI] [Full Text]

A resource for large-scale RNA-interference-based screens in mammals
Paddison PJ,
Silva JM,
Conklin DS,
Schlabach M,
Li M,
Aruleba S,
Balija V,
OShaughnessy A,
Gnoj L,
Scobie K,
Chang K,
Westbrook T,
Cleary M,
Sachidanandam R,
McCombie WR,
Elledge SJ,
Hannon GJ

Nature
  428 (6981): 427-31; Mar 25 2004  
[Abstract]
[DOI] [Full Text]

Dicer is essential for mouse development
Bernstein E,
Kim SY,
Carmell MA,
Murchison EP,
Alcorn H,
Li MZ,
Mills AA,
Elledge SJ,
Anderson KV,
Hannon GJ

Nature Genetics
  35 (3): 215-217; Nov 2003  
[Abstract]
[DOI] [Full Text]

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner
Hirao A,
Cheung A,
Duncan G,
Girard PM,
Elia AJ,
Wakeham A,
Okada H,
Sarkissian T,
Wong JA,
Sakai T,
de Stanchina E,
Bristow RG,
Suda T,
Lowe SW,
Jeggo PA,
Elledge SJ,
Mak TW

Molecular and Cellular Biology
  22 (18): 6521-6532; Sep 2002  
[Full Text]

Formation and Activation of a Cyclin E-Cdk2 Complex During the G(1)-Phase of the Human Cell-Cycle
Koff A,
Giordano A,
Desai D,
Yamashita K,
Harper JW,
Elledge S,
Nishimoto T,
Morgan DO,
Franza BR,
Roberts JM

Science
  257 (5077): 1689-1694; Sep 1992  
[Abstract]
[Full Text]


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